摘要
胰腺癌(PC)因缺乏早期特异性诊断,加上其对大多数可用治疗方案的耐药性,使PC成为一个临床难题。目前,对PC的治疗方法和治疗效果有限,因此需要基于对PC进展相关分子机制的理解,开发新的诊断、治疗策略。microRNA(miRNA)是非编码的小RNA,通过翻译后过程中可调节多种蛋白的表达,从而影响细胞分化、生物发育、肿瘤发生和发展等方面。随着现代生物技术的不断发展,发现miRNA具有高度的稳定性和组织特异性,符合成为早期生物标志物和预后因子的要求。此外,了解PC中的miRNA发挥的作用及其机制,可能会作为未来分子水平PC治疗的新方法。因此,本研究就miRNA在PC生物标志物、预后标志物和临床靶点治疗中的应用作一综述,拟为将来解决PC诊断、治疗提供研究方向和思路。
The lack of an early specific diagnosis of pancreatic cancer(PC),coupled with its resistance to most available treatment options,makes PC a clinical challenge.Currently,the therapeutic methods and efficacy for PC are limited,thus requiring the development of new diagnostic and therapeutic strategies based on understanding the molecular mechanisms related to PC progression.MicroRNA(miRNA)was a small RNA of coding by regulating a variety of protein expression in the process of translation after affecting cell differentiation,biological development,development of tumor,etc.With the continuous development of modern biotechnology,it has been found that miRNA has high stability and tissue specificity,which meets the requirements of becoming an early biomarker and prognostic factor.In addition,understanding the role and mechanism of miRNA in PC may serve as a new approach for the treatment of pancreatic cancer at the molecular level in the future.Therefore,this article provides a review of the application of miRNA in PC biomarkers,prognostic markers,and clinical target therapy,aiming to provide research directions and ideas for solving PC problems in the future.
作者
姜玲
付卿桦
陈涛
王子帅
孙延财
高马欣瑶
王隽善
姜颖
JIANG Ling;FU Qinghua;CHEN Tao;WANG Zishuai;SUN Yancai;GAO Maxinyao;WANG Junshan;JIANG Ying(School of Basic Medicine,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;The first Clinical Medical College,School of Basic Medicine and Graduate School of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
出处
《宁夏医科大学学报》
2024年第7期722-728,共7页
Journal of Ningxia Medical University
基金
国家自然科学基金项目(81804158)
黑龙江省留学归国人员科学基金项目(LC2015032)
黑龙江中医药大学大学生科技创新基金项目(北豆根及其有效成分蝙蝠葛碱通过MicroRNA-301a-3p介导的RUNX3/TGF-β信号通路诱导胰腺癌细胞凋亡机制研究)
黑龙江省普通本科高等学校青年创新人才培养计划金项目(UNPYSCT-2016079)
黑龙江中医药大学博士创新基金项目(SUMO化途径靶向抗肿瘤中草药筛选模型的建立及应用2013bs01)。
