摘要
内质网是参与蛋白质折叠和调控糖脂代谢行为的膜性管道系统,胰岛素的早期合成就在这里发生。哺乳动物细胞具备适应性调节内质网生产负荷、维持内质网稳态的分子网络。多种因素诱导了内质网功能紊乱,超出细胞自我修复能力的内质网应激是机体病理生理学改变及细胞死亡结局的重要风险事件。关注传统信号通路、炎症因子及转录因子等层面的调控线索,探索新出现的临床证据和中西医学药物,对改善胰岛素抵抗、维持细胞内质网生理功能有着深远的影响。本文将对相关研究进展及成果进行综述。
The endoplasmic reticulum is a membranous pipeline system involved in protein folding and regulating glucose and lipid metabolism behavior,where early insulin synthesis occurs.Mammalian cells possess a molecular network that adaptively regulates endoplasmic reticulum production load and maintains endoplasmic reticulum homeostasis.Multiple factors induce dysfunction of the endoplasmic reticulum,and endoplasmic reticulum stress beyond cellular self-repair ability is an important risk event for pathological and physiological changes in the body and cell death outcomes.Focusing on the regulatory clues of traditional signaling pathways,inflammatory factors,and transcription factors,exploring emerging clinical evidence and traditional Chinese and Western medicine drugs,has a profound impact on im proving insulin resistance and maintaining the physiological function of the endoplasmic reticulum.This paper will provide a review of relevant research progress and achievements.
作者
兰晋杰
张海生
LAN Jinjie;ZHANG Haisheng(Shanxi University of Chinese Medicine,Shanxi,Taiyuan 030000,China;The Hospital of Shanxi University of Chinese Medicine,Shanxi,Taiyuan 030000,China)
出处
《中国医药科学》
2024年第16期22-25,63,共5页
China Medicine And Pharmacy
基金
国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)
山西省中医药管理局科研课题项目(2022ZYYC022)。
关键词
胰岛素抵抗
内质网应激
氧化应激
分子机制
中医药
Insulin resistance
Endoplasmic reticulum stress
Oxidative stress
Molecular mechanism
Chinese medicine
