摘要
目的探讨布地奈德联合特布他林雾化吸入治疗小儿支气管炎的疗效及作用机制。方法按随机数表法将2021年1月至2022年10月台前县人民医院诊治的100例支气管炎患儿分为对照组和研究组,每组各50例。所有患儿入院后接受常规治疗,对照组给予特布他林治疗,研究组在特布他林基础上给予布地奈德治疗,连续治疗1周。对比两组疗效、症状体征改善时间及治疗前后炎症反应、肺功能、免疫功能变化,并对比两组不良反应发生率。结果研究组治疗有效率(94.00%)高于对照组(80.00%),差异有统计学意义(P<0.05)。各项症状体征改善时间对比,研究组时间短于对照组,差异有统计学意义(P<0.05)。治疗后,研究组白细胞介素-8(IL-8)、C反应蛋白(CRP)、降钙素原(PCT)及肿瘤坏死因子-α(TNF-α)水平较对照组更低,差异有统计学意义(P<0.05)。治疗后,研究组第一秒用力呼气量表(FEV_(1))/用力肺活量(FVC)、呼气峰值流速(PEF)较对照组更高,差异有统计学意义(P<0.05)。治疗后,研究组CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)水平高于对照组,而CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论支气管炎患儿采用布地奈德联合特布他林雾化吸入用药方案疗效确切,可减轻症状,抑制炎症反应,有助于改善患儿肺功能及免疫功能,临床安全性良好,值得临床应用。
Objective To investigate the efficacy and mechanism of budesonide combined with terbutaline nebulization in the treatment of pediatric bronchitis.Methods According to the random number table method,100 children with bronchitis treated at Taiqian County People’s Hospital from January 2021 to October 2022 were divided into a control group and a study group,with 50 cases in each group.All children received conventional treatment after admission.The control group was treated with terbutaline,while the study group was treated with budesonide in addition to terbutaline for one week.The efficacy,symptom improvement time,inflammatory response,lung function,immune function changes before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The treatment efficacy in the study group(94.00%)was higher than that in the control group(80.00%),with statistically significant differences(P<0.05).The symptom improvement time in the study group was shorter than that in the control group,with statistically significant differences(P<0.05).After treatment,the levels of interleukin-8(IL-8),C-reactive protein(CRP),procalcitonin(PCT),and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the forced expiratory volume in one second(FEV_(1))/forced vital capacity(FVC)and peak expiratory flow(PEF)in the study group were higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,while the level of CD8^(+)was lower than that in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of budesonide and terbutaline nebulization in the treatment of pediatric bronchitis is effe
作者
李爱平
刘敏
LI Aiping;LIU Min(Department of PediatricsⅡ,Taiqian County People’s Hospital,Puyang Henan 457600,China)
出处
《临床研究》
2024年第9期58-61,共4页
Clinical Research
关键词
小儿支气管炎
布地奈德
特布他林
肺功能
安全性
炎症反应
pediatric bronchitis
budesonide
terbutaline
lung function
safety
inflammatory response
