摘要
目的分析妊娠期糖尿病治疗中应用饮食运动疗法联合门冬胰岛素、地特胰岛素的效果,同时分析治疗前后组间血糖指标差异。方法选取2022年4月—2023年4月福州伽禾伽美医院收治的80例妊娠期糖尿病患者为研究对象,按照不同的治疗方法分为对照组和观察组,每组40例。两组均行饮食运动治疗。对照组应用门冬胰岛素治疗,观察组在对照组治疗的基础上加用地特胰岛素治疗。比较两组血糖指标[空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial plasma glucose,2 hPG)、糖化血红蛋白(gly⁃cated hemoglobin A1c,HbAlc)]、血清指标[同型半胱氨酸(homocysteine,HCY)、胱抑素C(cystatin C,CysC)]、剖宫产率、不良结局(新生儿呼吸窘迫、巨大儿、新生儿低血糖)发生率。结果观察组FPG、2 hPG及HbA1c水平均低于对照组,差异有统计学意义(P均<0.05)。观察组HCY、CysC水平均低于对照组,差异有统计学意义(P均<0.05)。观察组剖宫产率为5.00%(2/40),低于对照组的25.00%(10/40),差异有统计学意义(χ^(2)=5.186,P=0.023)。观察组新生儿不良结局发生率低于对照组,差异有统计学意义(P<0.05)。结论饮食运动疗法结合门冬胰岛素、地特胰岛素治疗妊娠期糖尿病,有利于控制血糖,调节血清指标,改善母婴结局。
Objective To analyze the effect of diet and exercise therapy combined with insulin aspart and insulin de-temir in the treatment of gestational diabetes mellitus,and to analyze the difference of blood glucose indexes between the groups before and after treatment.Methods A total of 80 patients with gestational diabetes mellitus admitted to Fuzhou Jiahe Jiamei Hospital from April 2022 to April 2023 were selected as the research objects.According to differ-ent treatment methods,they were divided into control group and observation group,with 40 cases in each group.Both groups were treated with diet and exercise.The control group was treated with insulin aspart,and the observation group was treated with insulin detemir on the basis of the control group.The blood glucose indexes[fasting plasma glu-cose(FPG),2-hour postprandial plasma glucose(2 hPG),glycated hemoglobin A1c(HbA1c)],serum indexes[homo-cysteine(HCY),cystatin C(CysC)],cesarean section rate,and incidence of adverse outcomes(neonatal respiratory dis-tress,macrosomia,neonatal hypoglycemia)were compared between the two groups.Results The levels of FPG,2 hPG and HbA1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of HCY and CysC in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The cesarean section rate of the observation group was 5.00%(2/40),which was lower than 25.00%(10/40)of the control group,and the difference was statistically significant(χ^(2)=5.186,P=0.023).The incidence of neonatal adverse outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Diet and exercise therapy combined with insulin aspart and insulin detemir in the treatment of gestational diabetes is conducive to con-trolling blood glucose,regulating serum indicators and improving maternal and infant outcomes.
作者
陈雪梅
雷海霞
陈阳钗
CHEN Xuemei;LEI Haixia;CHEN Yangchai(Department of Obstetrics and Gynecology,Fuzhou Jiahe Jiamei Hospital,Fuzhou 350007,Fujian,China)
出处
《糖尿病新世界》
2024年第11期100-103,共4页
Diabetes New World
关键词
饮食运动疗法
门冬胰岛素
地特胰岛素
妊娠期糖尿病
血糖指标
Diet and exercise therapy
Insulin aspart
Insulin detemir
Gestational diabetes mellitus
Blood glucose index
