摘要
目的:观察胰胆舒胶囊联合奥曲肽注射液治疗肝郁气滞型重症急性胰腺炎(SAP)患者的效果。方法:选取2020年6月至2023年6月该院收治的80例肝郁气滞型SAP患者进行前瞻性研究,按照随机数字表法分为研究组和对照组各40例。对照组静脉滴注醋酸奥曲肽注射液治疗,研究组在对照组基础上口服胰胆舒胶囊治疗。比较两组临床疗效,治疗前后中医证候积分、血清淀粉酶和脂肪酶水平、血清炎性因子[C反应蛋白(CRP)和降钙素原(PCT)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,研究组脘腹胀痛、恶心呕吐、嗳气呃逆等中医证候积分及血清淀粉酶、脂肪酶、CRP、PCT水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胰胆舒胶囊联合奥曲肽注射液治疗SAP患者效果显著,能够降低中医证候积分及血清淀粉酶、脂肪酶、CRP、PCT水平,效果优于单用奥曲肽治疗。
Objective:To observe effects of Yidanshu capsules combined with Octreotide injection in treatment of severe acute pancreatitis(SAP)of liver qi stagnation type.Methods:A prospective study was conducted on 80 patients with SAP of liver qi stagnation type admitted to this hospital from June 2020 to June 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Octreotide acetate injection intravenously,while the study group was treated with Yidanshu capsules orally on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores,the serum amylase and lipase levels,and the serum inflammatory factors[C-reactive protein(CRP)and procalcitonin(PCT)]levels before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 95.00%(38/40),which was higher than 80.00%(32/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as abdominal distension and pain,nausea and vomiting,belching and hiccup,the levels of serum amylase,lipase,CRP and PCT in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Yidanshu capsules combined with Octreotide injection has a significant effect in the treatment of the SAP patients,which can reduce the TCM syndrome scores and the serum amylase,lipase,CRP and PCT levels.Moreover,it is superior to simple Octreotide treatment.
作者
张博
李少勇
ZHANG Bo;LI Shaoyong(Nanyang Yuxi Jianhe Hospital,Emergency Internal Medicine Department,Nanyang 474500 Henan,China;Nanyang Yuxi Jianhe Hospital,Digestive Medicine Department,Nanyang 474500 Henan,China)
出处
《中国民康医学》
2024年第17期97-100,共4页
Medical Journal of Chinese People’s Health
关键词
胰胆舒胶囊
奥曲肽
重症急性胰腺炎
中西医结合
炎性因子
Yidanshu capsules
Octreotide
Severe acute pancreatitis
Integrated traditional Chinese and Western medicine
Inflammatory factor
