摘要
目的:观察天麻钩藤饮加减联合依达拉奉治疗缺血性卒中肝阳上亢证患者的效果。方法:选取2021年3月至2023年8月该院收治的108例缺血性卒中肝阳上亢证患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各54例。对照组采用依达拉奉治疗,研究组在对照组基础上联合天麻钩藤饮加减治疗,比较两组临床疗效,治疗前后中医证候积分、肢体运动功能[Fugl-Meyer运动功能评分量表(FMA)]评分、神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]水平,以及不良反应发生率。结果:研究组治疗总有效率为94.44%(51/54),高于对照组的81.48%(44/54),差异有统计学意义(P<0.05);治疗后,两组头晕目眩、半身不遂、面赤耳鸣等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组FMA评分均高于治疗前,且研究组高于对照组,两组NIHSS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组ET-1水平均低于治疗前,且研究组低于对照组,两组NO水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计意义(P>0.05)。结论:天麻钩藤饮加减联合依达拉奉治疗缺血性卒中肝阳上亢证患者可提高治疗总有效率和肢体运动功能评分,改善血管内皮功能指标水平,降低中医证候积分和神经功能缺损程度评分,其效果优于单纯依达拉奉治疗。
Objective:To observe effects of modified Tianma Gouteng decoction combined with Edaravone in treatment of ischemic stroke patients with liver-yang hyperactivity syndrome.Methods:A prospective study was conducted on 108 patients with ischemic stroke and liver-yang hyperactivity syndrome admitted to the hospital from March 2021 to August 2023.According to the random number table method,they were divided into study group and control group,54 cases in each group.The control group was treated with Edaravone,while the study group was treated with modified Tianma Gouteng decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the limb motor function[Fugel-Meyer assessment(FMA)]score,the neurological deficit degree[National Institutes of Health stroke scale(NIHSS)]score,the vascular endothelial function index[endothelin-1(ET-1),nitric oxide(NO)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.44%(51/54),which was higher than 81.48%(44/54)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as dizziness,hemiplegia and facial redness and tinnitus in the two groups were lower than those before treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The FMA scores of the two groups were higher than those before treatment,and that in the study group was higher than that in the control group;the NIHSS scores of the two groups were lower than those before treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of ET-1 in the two groups were lower than those before treatment,and that in the study group was lower than that in the control group;the levels of NO in the two groups were higher than those before treatment,and
作者
邢颖
徐亚民
李战平
阎钊
XING Ying;XU Yamin;LI Zhanping;YAN Zhao(Department of Preventive Treatment of Xuchang Hospital of Traditional Chinese Medicine,Xuchang 461000 Henan,China)
出处
《中国民康医学》
2024年第17期86-88,92,共4页
Medical Journal of Chinese People’s Health
关键词
天麻钩藤饮加减
依达拉奉
肝阳上亢证
缺血性卒中
血管内皮功能
中医证候积分
神经功能缺损程度
Modified Tianma Gouteng decoction
Edaravone
Liver-yang hyperactivity syndrome
Ischemic stroke
Vascular endothelial function
TCM syndrome score
Neurological deficit degree
