摘要
目的:观察低分子肝素钙联合硫酸镁治疗重度子痫前期患者的效果。方法:选取2020年1月至2023年2月该院收治的88例重度子痫前期患者进行前瞻性研究,按随机数字表法将其分为对照组(n=44)与观察组(n=44)。对照组采用硫酸镁治疗,观察组在对照组基础上联合低分子肝素钙注射液治疗。比较两组临床疗效,治疗前后血液流变学指标[血浆黏度(PV)、纤维蛋白原(FIB)、红细胞沉降率(ESR)、血细胞比容(HCT)]水平,不良妊娠结局发生率,以及不良新生儿结局发生率。结果:观察组治疗总有效率为95.45%(42/44),高于对照组的75.00%(33/44),差异有统计学意义(P<0.05);治疗后,两组PV、FIB、ESR、HCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察剖宫产、早产、胎盘早剥、产后出血发生率均低于对照组,差异有统计学意义(P<0.05);观察组胎儿窘迫、新生儿窒息发生率均低于对照组,差异有统计学意义(P<0.05)。结论:低分子肝素钙联合硫酸镁治疗重度子痫前期患者可提高治疗总有效率,降低血液流变学指标水平、不良妊娠结局发生率和不良新生儿结局发生率,其效果优于单纯硫酸镁治疗。
Objective:To observe effects of low molecular weight Heparin calcium combined with Magnesium sulfate in treatment of patients with severe preeclampsia.Methods:A prospective study was conducted on 88 patients with severe preeclampsia admitted to the hospital from January 2020 to February 2023.They were divided into control group(n=44)and observation group(n=44)by using the random number table method.The control group was treated with Magnesium sulfate,while the observation group was treated with low molecular weight Heparin calcium injection on the basis of that of the control group.The clinical efficacy,the levels of hemorheology indexes[plasma viscosity(PV),fibrinogen(FIB),erythrocyte sedimentation rate(ESR),hematocrit(HCT)]before and after the treatment,the incidence of adverse pregnancy outcomes,and the incidence of adverse neonatal outcomes were compared between the two groups.Results:The total effective rate of the observation group was 95.45%(42/44),which was higher than 75.00%(33/44)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PV,FIB,ESR and HCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidences of cesarean section,premature delivery,placental abruption and postpartum hemorrhage in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of fetal distress and neonatal asphyxia in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Low molecular weight Heparin calcium combined with Magnesium sulfate in the treatment of the patients with severe preeclampsia can improve the total effective rate of treatment and reduce the levels of hemorheology indexes,the incidence of adverse pregnancy outcomes and the incidence of advers
作者
张艳
刘艳
高慧
ZHANG Yan;LIU Yan;GAO Hui(st Department of Obstetrics of Hopeshine-Minsheng Hospital of Xinzheng,Zhengzhou 451100 Henan,China)
出处
《中国民康医学》
2024年第17期44-46,共3页
Medical Journal of Chinese People’s Health
关键词
重度子痫前期
低分子肝素钙
硫酸镁
血液流变学
不良妊娠结局
不良新生儿结局
Severe preeclampsia
Low molecular weight Heparin calcium
Magnesium sulfate
Hemorheology
Adverse pregnancy outcome
Adverse neonatal outcome
