摘要
目的:观察注射用矛头蝮蛇血凝酶联合奥美拉唑治疗老年急性上消化道出血患者的效果。方法:选取2022年1月至2024年2月该院收治的60例老年急性上消化道出血患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各30例。对照组采用注射用奥美拉唑钠治疗,观察组在对照组基础上联合注射用矛头蝮蛇血凝酶治疗,比较两组出血停止时间、腹痛消失时间、住院时间、凝血功能指标(凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原)水平、应激指标(血清皮质醇、去甲肾上腺素)水平和不良反应发生率。结果:观察组出血停止时间、腹痛消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组凝血酶原时间和活化部分凝血活酶时间短于治疗前,且观察组短于对照组,两组纤维蛋白原水平高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05);治疗后,两组血清皮质醇、去甲肾上腺素等应激指标水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:注射用矛头蝮蛇血凝酶联合奥美拉唑治疗老年急性上消化道出血患者可缩短出血停止时间、腹痛消失时间和住院时间,改善凝血功能指标水平,以及降低应激指标水平,效果优于单纯奥美拉唑治疗。
Objective:To observe effects of Hemocoagulase bothrops atrox for injection combined with Omeprazole in treatment of elderly patients with acute upper digestive tract hemorrhage.Methods:A prospective study was conducted on 60 elderly patients with acute upper digestive tract hemorrhage admitted to this hospital from January 2022 to February 2024.According to the random number table method,they were divided into observation group and control group,30 cases in each group.The control group was treated with Omeprazole sodium for injection,while the observation group was treated with Hemocoagulase bothrops atrox for injection on the basis of that of the control group.The bleeding stop time,the abdominal pain disappearance time,the hospitalization time,the coagulation function index(prothrombin time,activated partial thromboplastin time,fibrinogen)levels,the stress index(serum cortisol,norepinephrine)levels,and the incidence of adverse reactions were compared between the two groups.Results:The bleeding stop time,the abdominal pain disappearance time and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the prothrombin time and the activated partial thromboplastin time in the two groups were shorter than those before the treatment,and those in the observation group were shorter than those in the control group;the levels of fibrinogen in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of stress indexes such as serum cortisol and norepinephrine in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the
作者
刘兰芳
LIU Lanfang(Department of Geriatrics(rehabilitation)of the Third Affiliated Hospital of Gannan Medical College,Ganzhou 341000 Jiangxi,China)
出处
《中国民康医学》
2024年第17期32-34,共3页
Medical Journal of Chinese People’s Health
关键词
注射用矛头蝮蛇血凝酶
奥美拉唑
老年
急性上消化道出血
凝血功能
应激
Hemocoagulase bothrops atrox for injection
Omeprazole
Elderly
Acute upper digestive tract hemorrhage
Coagulation function
Stress
