摘要
研究了(1R,2S)-2-氟环丙胺对甲苯磺酸盐的合成工艺。以丁二烯为原料,经过成环、氧化、还原、拆分等反应,设计合成(1S,2S)-2-氟环丙甲酸,通过考察与优化确定了最佳反应条件;进一步制得目标产物(1R,2S)-2-氟环丙胺对甲苯磺酸盐,产物收率达到75%。
The synthesis process of(1R,2S)⁃2⁃fluorocyclopropylamine p⁃toluenesulfonate is studied.(1S,2S)⁃2⁃fluorocyclopropanecarboxylic acid is synthesized from butadiene through cyclization,oxidation,reduction,resolution,and other reactions,and the optimal reaction conditions are determined.Further,(1R,2S)⁃2⁃fluoro⁃cyclopropylamine p⁃methanesulfonate,the target product,is obtained with a total yield of 75%.
作者
吕红兵
邱滔
LV Hong-bing;QIU Tao(School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China;Changzhou BOHIV Pharmaceutical Technology Co.,Ltd.,Changzhou 213164,China)
出处
《现代化工》
CAS
CSCD
北大核心
2024年第S01期218-221,225,共5页
Modern Chemical Industry
