摘要
目的运用孟德尔随机化(MR)探究炎症性肠病(IBD)与银屑病(PsO)的因果关系。方法选取炎症性肠病2个亚型克罗恩病(CD)及溃疡性结肠炎(UC)样本进行分析,克罗恩病和溃疡性结肠炎样本量分别为20883例和47745例。银屑病样本量为44161例。MR分析以逆方差加权(IVW)法为主要分析方法,以比值比(OR)评价炎症性肠病与银屑病风险的因果关系。分别采用IVW和MR Egger法进行Cochran Q异质性检验,MR pleiotropy test函数、MR Egger回归截距进行多效性检验,MR leave one out plot函数进行敏感性分析,并计算F值(F<10)以判断是否存在弱工具变量偏倚。结果银屑病不会增加克罗恩病的患病风险(OR=1.14,95%CI:0.94~1.38;P>0.05),也不是溃疡性结肠炎的风险因素(OR=1.09,95%CI:0.95~1.25;P>0.05);克罗恩病是银屑病的风险因素(OR=1.21,95%CI:1.09~1.34;P<0.05),而溃疡性结肠炎与银屑病发病无关(OR=1.02,95%CI:0.91~1.15;P>0.05)。结论克罗恩病是银屑病的风险因素,银屑病并非克罗恩病的风险因素,而溃疡性结肠炎与银屑病发病无关。
Objective To investigate the causal relationship between inflammatory bowel disease(IBD)and psoriasis(PsO)using Mendelian randomization(MR).Methods Two IBD subtypes,Crohn′s disease(CD)and ulcerative colitis(UC),were analyzed.The sample sizes for CD and UC were 20883 and 47745 cases,respectively.The PsO sample size was 44161 cases.The inverse variance weighting(IVW)method was primarily employed for the MR analysis,with odds ratios(OR)used to assess the causal relationship between IBD and PsO risk.Cochran′s Q heterogeneity test was performed using IVW and MR Egger methods.Pleiotropy was tested using the MR pleiotropy test function and MR Egger regression intercept.Sensitivity analysis was conducted using the MR leave-one-out plot function.The F-value(F<10)was calculated to assess the presence of weak instrument variable bias.Results PsO did not increase the risk of CD(OR=1.14,95%CI:0.94-1.38;P>0.05)and was not a risk factor for UC(OR=1.09,95%CI:0.95-1.25;P>0.05).In contrast,CD was a risk factor for PsO(OR=1.21,95%CI:1.09-1.34;P<0.05),while UC was not associated with PsO(OR=1.02,95%CI:0.91-1.15;P>0.05).Conclusion CD is a risk factor for PsO,while PsO is not a risk factor for CD,and UC is not associated with PsO.
作者
贺守炎
潘燎
陈瑶
王真权
HE Shouyan;PAN Liao;CHEN Yao;WANG Zhenquan(Department of Anorectum,the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410000,China;Department of Dermatology,the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410000,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2024年第9期982-988,共7页
The Chinese Journal of Dermatovenereology
基金
湖南省自然科学基金项目(2023JJ60040)
湖南省中医药科研计划项目(2021020)
长沙市自然科学基金项目(kq2202482)。
关键词
炎症性肠病
银屑病
孟德尔随机化
因果关系
Inflammatory bowel disease
Psoriasis
Mendelian randomization
Causal relationship
