摘要
目的探讨2型糖尿病(T2DM)患者中血清Wnt1诱导信号通路蛋白-1(WISP1)水平与血尿酸浓度的相关性。方法随机招募作者医院内分泌科T2DM患者146例,根据血尿酸的中位数分为高尿酸组和低尿酸组。测量2组身高、体重、腰围、臀围、内脏脂肪面积等一般人体学指标。检测血尿酸(SUA)、肝肾功能、血糖、血脂、C反应蛋白(CRP)、糖化血红蛋白A1c(HbA1c)、空腹C肽等指标。ELISA法测定血清WISP1含量。结果与低尿酸组比较,高尿酸组的血清WISP1水平更高(P=0.004)。Spearman相关分析显示,血清WISP1水平与SUA(r=0.139,P=0.040)、CRP(r=0.203,P=0.004)、HbA1c(r=0.185,P=0.006)呈正相关。多元逐步回归分析显示,WISP1水平独立影响血尿酸水平(β=0.220,P<0.001)。结论血清WISP1与T2DM患者血尿酸升高独立正相关。
Objective To investigate the correlation between serum Wnt1 induced signaling pathway protein 1(WISP1)levels and serum uric acid(SUA)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 146 T2DM patients were randomly recruited from the department of endocrinology of the authors'hospital.According to the median level of SUA,the patients were divided into either a high uric acid group or a low uric acid group.Height,weight,waist circumference,hip circumference,and visceral fat area were measured.The levels of SUA,hepatorenal function parameters,blood glucose,blood lipid,C-reactive protein(CRP),glycosylated hemoglobin A1c(HbA1c),and fasting C-peptide were detected.ELISA was used to measure the serum levels of WISP1.Results The patients in the high uric acid group had higher serum WISP1 levels than those in the low uric acid group(P=0.004).Spearman correlation analysis showed that WISP1 was positively correlated with SUA(r=0.139,P=0.040),CRP(r=0.203,P=0.004),and HbA1c(r=0.185,P=0.006).Multiple stepwise regression analysis demonstrated that WISP1 independently contributed to elevated serum uric acid levels(β=0.220,P<0.001).Conclusion Serum WISP1 independently and positively correlates with elevated SUA in type 2 diabetic patients.
作者
孙琳
韩萍萍
张碧琳
张军霞
Lin Sun;Pingping Han;Bilin Zhang;Junxia Zhang(The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;Department of Endocrinology,Central Theater Command General Hospital of the Chinese PLA,Wuhan 430070,China)
出处
《中华临床医师杂志（电子版）》
CAS
2024年第2期178-182,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
湖北省卫生健康科研基金重点支撑项目(WJ2021Z010)。
关键词
Wnt1诱导信号通路蛋白-l
2型糖尿病
血尿酸
胰岛素抵抗
Wntl induced signaling pathway protein-1(WISP1)
Type 2 diabetes mellitus
Blood uric acid
Insulin resistance
