摘要
临床发现,肠易激综合征(irritable bowel syndrome,IBS)患者普遍伴随着腹痛、腹泻等腹部不适症状,反复的腹痛不仅降低了患者的生活质量,还增加了医疗资源的负担。内脏高敏感(visceral hypersensitivity,VH)是IBS的核心病机之一,是引起IBS腹痛症状的主要原因。大量研究表明,针灸治疗IBS疗效突出,针灸可能通过抑制VH来缓解患者腹痛等不适症状,在临床上具有很高的应用价值。然而,针灸在治疗IBS的过程中如何调节VH来实现其镇痛作用还有待深入探讨。因此,本文将围绕VH这一核心因素,总结当前引起VH的相关因素,从脑肠轴、相关受体、肠道菌群及情志因素等方面探究针灸抑制VH的镇痛机制。
Clinical findings show that patients with irritable bowel syndrome(IBS)are commonly accompanied by abdominal discomfort symptoms such as abdominal pain and diarrhea,and recurrent abdominal pain not only reduces the quality of life of patients,but also increases the burden of medical resources.Visceral hypersensitivity(VH)is one of the core pathomechanisms of IBS and is the main cause of abdominal pain symptoms in IBS.Numerous studies have shown that acupuncture has outstanding efficacy in the treatment of IBS,and acupuncture may alleviate patients'ab‐dominal pain and other uncomfortable symptoms by inhibiting VH,which is of high clinical value.However,how acupuncture regulates VH to achieve its analgesic effect in the treatment of IBS has yet to be thoroughly explored.Therefore,this paper will focus on the core factor of VH,sum‐marize the current relevant factors that cause VH,and explore the analgesic mechanism of VH inhibition by acupuncture from the aspects of brain gut axis,relevant receptors,intestinal flora and emotional factors.
作者
赖泽栋
裴丽霞
耿昊
陈璐
李锂
郭静
孙建华
LAI Ze-dong;PEI Li-xia;GENG Hao;CHEN Lu;LI Li;GUO Jing;SUN Jian-hua(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029)
出处
《中医康复》
2024年第10期1-6,共6页
Traditional Chinese Medicine Rehabilitation
基金
国家自然科学基金(82174489、82274630)
江苏省中医院高峰人才项目(y2021rc50、y2021rc04)。
关键词
肠易激综合征
针灸疗法
内脏高敏感
脑肠肽
镇痛
作用机制
irritable bowel syndrome
acupuncture therapy
visceral hypersensitivity
brain-gut peptide
analgesia
mechanism
