摘要
目的合并分析单纯火针治疗膝骨性关节炎的疗效与安全性及对炎症因子的作用,为临床决策提供循证依据。方法计算机检索数据库中有关火针治疗膝骨性关节炎的随机对照试验文献,检索时间从数据库建库至2023年4月。运用Cochrane偏倚风险评估工具对纳入的文献进行偏倚风险分析,采用RevMan 5.4软件对纳入研究的骨关节炎指数(WOMAC)评分、治疗有效率、膝关节疼痛视觉模拟评分法(VAS)评分和血清中白细胞介素-1(IL-1)水平进行Meta分析。结果Meta分析结果显示,火针疗法治疗膝骨性关节炎在降低WOMAC评分、提高治疗有效率、降低膝关节疼痛VAS评分、降低血清中IL-1水平方面均优于对照疗法。结论本次合并分析的文献结果表明火针疗法对于改善膝骨性关节炎疗效和安全性较突出,但仍需更多样本量大、高质量、多方向的高水平研究进一步证实。
Objective To analyze the efficacy and safety of fire needle in the treatment of knee osteoarthritis and its influence on inflammatory factors,so as to provide evidence-based evidence for clinical decision-making.Methods Randomized controlled trials related to the treatment of knee osteoarthritis with fire needle were searched by computer retrieval databases.The search time was from the establishment of the database to April 2023.Cochrane bias risk assessment tool was used to conduct bias risk analysis of the included literatures,and Meta-analysis of Western Ontario and McMaster Universities osteoarthritis index(WOMAC)score,treatment response rate,knee visual analogue scale(VAS)score and serum interleukin-1(IL-1)level was performed using ReviewMan 5.4 software.Results The results of Meta-analysis showed that fire needle was superior to control therapy in reducing WOMAC score,improving treatment response rates,decreasing knee VAS score,and decreasing serum IL-1 level in knee osteoarthritis.Conclusion The literature results of this pooled analysis show that fire needle therapy is effective and safe in improving knee osteoarthritis,but more high-level studies with large sample size,high quality and multiple directions are needed to further confirm this.
作者
赵艳霞
林忆诗
谢丽琴
韦俨童
李曾琳
黄婉尧
张剑英
王钰皓
ZHAO Yan-xia;LIN Yi-shi;XIE Li-qin(Clinical College of Traditional Chinese and Western Medicine,Guangzhou Medical University,Guangzhou 510000,China)
出处
《中国现代药物应用》
2024年第16期139-144,共6页
Chinese Journal of Modern Drug Application
基金
广东省中医药局科研项目(项目编号:20231258)
广州医科大学2023年中西医临床医学专业教学培育项目(广医中医发[2023]11号)。
