摘要
目的:探究益髓颗粒联合甲泼尼龙琥珀酸钠治疗急性期多发性硬化症(MS)的效果。方法:选择2022年1月—2023年7月在天水市第一人民医院治疗的急性期MS患者62例,应用随机数字表法将其分为对照组(予以甲泼尼龙琥珀酸钠)及观察组(联合益髓颗粒),各31例。对比两组扩展残疾状态量表(EDSS)、炎症因子、神经因子、血清T淋巴细胞亚群、脑脊液T淋巴细胞亚群。结果:治疗后,两组EDSS评分均降低,观察组低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组γ干扰素(IFN-γ)、基质金属蛋白酶-9(MMP-9)均降低,白细胞介素-12p40(IL-12p40)均升高,观察组IFN-γ、MMP-9均低于对照组,IL-12p40高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组转化生长因子-β_(1)(TGF-β_(1))均升高,S-100蛋白、Tau蛋白均降低,观察组TGF-β_(1)高于对照组,S-100蛋白、Tau蛋白均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组血清CD4^(+)、CD8^(+)均升高,CD4^(+)/CD8^(+)均降低,差异均有统计学意义(P<0.05);治疗后,两组脑脊液CD4^(+)、CD4^(+)/CD8^(+)均降低,CD8^(+)均升高,差异均有统计学意义(P<0.05)。结论:益髓颗粒联合甲泼尼龙琥珀酸钠治疗急性期MS可降低炎症因子,改善神经功能,调节神经因子、T淋巴细胞亚群,延缓免疫应答。
Objective:To investigate the effect of Yisui Granules combined with Methylprednisolone Sodium Succinate in the treatment of acute multiple sclerosis(MS).Method:A total of 62 patients with acute MS treated in First People's Hospital of Tianshui from January 2022 to July 2023 were selected and divided into control group(given Methylprednisolone Sodium Succinate)and observation group(combined with Yisui Granules)by random number table method,with 31 cases in each group.The extended disability status scale(EDSS),inflammatory factors,neurofactors,serum T lymphocyte subsets and cerebrospinal fluid T lymphocyte subsets were compared between the two groups.Result:After treatment,the EDSS scores were decreased in both groups,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,interferon-γ(IFN-γ)and matrix metalloproteinase-9(MMP-9)were decreased in both groups,interleukin-12p40(IL-12p40)were increased in both groups,and IFN-γand MMP-9 in observation group were lower than those in control group,IL-12p40 was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,transforming growth factor-β_(1)(TGF-β_(1))were increased in both groups,S-100 protein and Tau protein were decreased in both groups,and TGF-β_(1)in observation group was higher than that in control group,S-100 protein and Tau protein were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,serum CD4^(+) and CD8^(+) were increased in both groups,and CD4^(+)/CD8^(+)were decreased,the differences were statistically significant(P<0.05).After treatment,cerebrospinal fluid CD4^(+) and CD4^(+)/CD8^(+) were decreased in both groups,and CD8 were increased,the differences were statistically significant(P<0.05).Conclusion:Yisui Granules combined with Methylprednisolone Sodium Succinate in the treatment of acute MS can reduce inflammatory factors,improve nerve function,regulate
作者
颉满珍
JIE Manzhen(Department of Neurology,First People's Hospital of Tianshui,Tianshui 741000,China)
出处
《中国医学创新》
CAS
2024年第23期19-23,共5页
Medical Innovation of China
