摘要
目的 分析甲氨蝶呤联合糖皮质激素对肉芽肿性小叶性乳腺炎(GLM)的疗效及不良反应。方法 回顾性选取2019年9月至2021年12月于广东省中医院和广东省妇幼保健院进行治疗的GLM患者99例,根据患者的治疗方案不同,将34例甲氨蝶呤联合糖皮质激素治疗患者纳入联合治疗组,65例单纯使用糖皮质激素治疗患者纳入对照组。比较两组患者炎症因子水平、治疗效果及不良反应发生率。结果 联合治疗组的总有效率97.06%(33/34),高于对照组80.00%(52/65),差异有统计学意义(χ^(2)=4.038,P<0.05)。联合治疗组和对照组治疗后C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞计数(WBC)水平[分别是(19.78±4.74) mg·L^(-1)、(26.46±4.24) mg·L^(-1);(22.68±5.81) pg·m L^(-1)、(33.52±6.22) pg·m L^(-1);(7.14±0.84)10~9·m L^(-1)、(8.64±0.97) 10~9·m L^(-1)],低于治疗前[分别是(34.46±8.24) mg·L^(-1)、(33.52±7.81) mg·L^(-1);(39.77±10.24)pg·m L^(-1)、(40.13±11.05) pg·m L^(-1);(10.54±2.24) 10~9·m L^(-1)、(10.72±2.51) 10~9·m L^(-1)],且治疗后联合治疗组低于对照组(t=7.146、8.419、7.638,均P<0.05)。联合治疗组不良反应发生率11.76%(4/34),低于对照组30.77%(20/65)(χ^(2)=4.390,P<0.05)。结论 甲氨蝶呤联合糖皮质激素治疗方案可显著缓解GLM患者的临床症状,且安全性较高,具有临床应用价值。
Objective To investigate the efficacy and adverse reactions of methotrexate combined with glucocorticoids in the treatment of granulomatous lobular mastitis(GLM).Methods The clinical data of 99 patients with GLM treated in Guangdong Provincial Hospital of Traditional Chinese Medicine and Guangdong Maternal and Child Health Hospital from September 2019 to December 2021 were retrospectively analyzed.According to the patient’s treatment plan,34 patients treated with methotrexate combined with glucocorticoids were enrolled in the combined group and 65 patients treated with glucocorticoids alone were included in the control group.The inflammatory factor levels,treatment effect and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate was 97.06%(33/34)in the combined group,which was higher than that of 80.00%(52/65)in the control(χ^(2)=4.038,P<0.05).The levels of C-reactive protein(CRP),interleukin-6(IL-6)and white blood cell count(WBC)after treatment in the combined group and the control group were((19.78±4.74)mg·L^(-1),(26.46±4.24)mg·L^(-1);(22.68±5.81)pg·mL^(-1),(33.52±6.22)pg·mL^(-1);(7.14±0.84)109·mL^(-1),(8.64±0.97)109·mL^(-1)),respectively,which were lower than those before treatment((34.46±8.24)mg·L^(-1),(33.52±7.81)mg·L^(-1);(39.77±10.24)pg·mL^(-1),(40.13±11.05)pg·mL^(-1);(10.54±2.24)109·mL^(-1),(10.72±2.51)109·mL^(-1)).Meanwhile,they were significantly lower in the combined group than in the control(t=7.146,8.419,7.638,all P<0.05).The incidence of adverse reactions in the combined group was 11.76%(4/34),which was lower than that of 30.77%(20/65)in the control group(χ^(2)=4.390,P<0.05).Conclusion The treatment regimen of methotrexate combined with glucocorticoids can significantly alleviate the clinical symptoms of patients with GLM.Furthermore,it is highly safe and has clinical application value.
作者
陈斯琪
王蕾
邹妮倩
邹素文
Chen Si-qi;Wang Lei;Zou Ni-qian;Zou Su-wen(Department of Comprehensive Medicine,Zengcheng District Hospital of Traditional Chinese Medicine,Guangzhou 511300,China;Department of Breast Disease Treatment,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China;Department of Breast Disease Treatment,Guangxi International Zhuang Medicine Hospital,Nanning 530200,China;Breast Disease Prevention and Treatment Center,Guangdong Provincial Maternal and Child Health Hospital,Guangzhou 511400,China)
出处
《中国药物应用与监测》
CAS
2024年第4期446-449,共4页
Chinese Journal of Drug Application and Monitoring
关键词
甲氨蝶呤
糖皮质激素
肉芽肿性小叶性乳腺炎
疗效
不良反应
Methotrexate
Glucocorticoids
Granulomatous lobular mastitis
Therapeutic efficacy
Adverse reaction
