摘要
三价砷(ASⅢ)在临床上常用于治疗急性早幼粒细胞白血病(APL),疗效较为显著,但其自身毒性限制了临床应用范围。ASⅢ的主要排泄器官是肾脏,其肾毒性常导致肾脏结构和功能的严重受损。目前,ASⅢ致肾损伤的具体机制尚未完全阐明,且缺乏有效的预防和治疗手段。文章综述了ASⅢ致肾损伤的发病率和风险、致病机制和防治手段方面的研究进展。
Trivalent arsenic(ASⅢ)is commonly used in the management of acute promyelocytic leukemia(APL),with positive therapeutic outcomes,but its autotoxicity limits its clinical application.Serving as the main excretory organ for ASⅢ,the kidney is particularly susceptible to its nephrotoxic effects,which can result in significant structural and functional impairments.Nevertheless,the pathogenesis of kidney injury caused by ASⅢhas not been fully elucidated,and effective preventive and therapeutic strategies are lacking.This article provides a comprehensive review of research advances in the incidence and risk of the pathogenesis,prevention and treatment of nephrotoxicity associated with arsenic-induced renal injury.
作者
宋智勇
龚学忠
SONG Zhi-yong;GONG Xue-zhong(Department of Nephrology,Shanghai Municipal Hospital of Traditional Chinese medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《南昌大学学报（医学版）》
2024年第4期99-102,106,共5页
Journal of Nanchang University：Medical Sciences
基金
国家自然科学基金面上项目(82074387,81873280)。
关键词
三价砷
肾损伤
发病机制
中西医防治
trivalent arsenic
kidney injury
pathogenesis
prevention and treatment of Chinese and western medicine
