摘要
目的分析重度抑郁症(MDD)患者的肠道菌群特征及其代谢产物水平,并探讨其与炎症因子的关系。方法选取2020年5月—2023年5月于绍兴市第七人民医院接受治疗的98例MDD患者作为研究对象,再选取同期于该院接受健康检查的50例健康人群作为对照组。对比MDD患者与健康人群的肠道菌群代谢产物水平以及炎症因子水平差异,采用Pearson相关性分析肠道菌群代谢产物水平及其与炎症因子的关系。结果MDD组的IL-1β[(55.48±12.08)ng/L]等炎症因子水平高于对照组[(42.15±10.03)ng/L,t=7.124,P<0.001],MDD组的氧化三甲胺(TMAO)水平[(3.25±0.71)μmol/L]高于对照组[(1.37±0.24)μmol/L,t=23.694,P<0.001],MDD组短链脂肪酸(SCFAs)总量[(18.26±2.94)μg/g]均低于对照组[(22.03±3.25)μg/g,t=6.889,P<0.001];MDD组的TMAO和IL-1β(r=0.404)、IL-6(r=0.503)、CRP(r=0.454)水平呈正相关,和TNF-α水平(r=-0.348)呈负相关,SCFAs和IL-1β(r=-0.478)、IL-6(r=-0.378)、CRP水平(r=-0.416)均呈负相关关系(P<0.05)。结论MDD患者肠道菌群代谢产物TMAO、SCFAs的水平与炎症因子水平密切相关,恢复肠道菌群代谢产物的平衡可在MDD的治疗中发挥重要作用。
ObjectiveTo analyze the characteristics of intestinal flora and the level of its metabolites in patients with major depressive disorder(MDD),and to explore its relationship with inflammatory factors.MethodsA total of 98 MDD patients who were treated in Shaoxing Seventh People's Hospital from May 2020 to May 2023 were selected as the research object and 50 healthy people who received health examination in the same period were selected as the control group.The levels of intestinal flora metabolites and inflammatory factors between MDD patients and healthy people were compared,and the relationship between intestinal flora metabolites and inflammatory factors was analyzed by Pearson correlation.ResultsThe levels of IL-1β[(55.48±12.08)ng/L]and other inflammatory factors in the MDD group were higher than those in the control group[(42.15±10.03)ng/L,t=7.124,P<0.001].The trimetlylamine oxide(TMAO)level in the MDD group[(3.25±0.71)μmol/L]was higher than that in the control group[(1.37±0.24)μmol/L,t=23.694,P<0.001].The total amount of short chain fatty acids(SCFAs)in the MDD group[(18.26± 2.94)μg/g]was lower than that in the control group[(22.03±3.25)μg/g,t=6.889,P<0.001].In the MDD group,the TMAO level was positively correlated with the level of IL-1β(r=0.404),IL-6(r=0.503),and CRP(r=0.454),and negatively correlated with TNF-αlevel(r=-0.348).The levels of SCFAs and IL-1β(r=-0.478),IL-6(r=-0.378),and CRP(r=-0.416)were negatively correlated(P<0.05).ConclusionThe levels of TMAO and SCFAs in the intestinal flora of MDD patients are closely related to the levels of inflammatory factors,and restoring the balance of intestinal flora metabolites plays an important role in the treatment of MDD.
作者
王丽英
陈晶
WANG Liying;CHEN Jing(Department of Psychiatry,Shaoxing Seventh People's Hospital,Shaoxing,Zhejiang 312000,China)
出处
《中华全科医学》
2024年第9期1563-1566,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2023KY1272)。
关键词
重度抑郁症
肠道菌群
菌群代谢产物
炎症因子
短链脂肪酸
氧化三甲胺
Major depressive disorder
Intestinal flora
Metabolites of flora
Inflammatory factor
Short chain fatty acids
Trimetlylamine oxide
