摘要
【目的】观察培元养心针灸法联合骨补丸治疗2型糖尿病合并骨质疏松症(T2DOP)的临床疗效。【方法】将70例T2DOP患者随机分为治疗组和对照组,每组各35例,对照组给予常规降糖与补钙治疗,治疗组在对照组的基础上,给予培元养心针灸法联合骨补丸治疗,连续治疗8周。治疗2个月后,评价2组患者的临床疗效,观察2组患者治疗前后血清骨钙素(OC)、总1型胶原氨基酸延长肽(PINP)、β-胶原特殊序列(β-CTX)和无机磷(P)等指标的变化情况,以及糖化血红蛋白(HbA1c)的情况。比较2组患者治疗前后疼痛视觉模拟量表(VAS)、汉密尔顿焦虑量表(HAMA)以及糖尿病患者生存质量特异性量表(DSQL)评分的变化情况。并评价2组的安全性及不良反应的发生情况,统计2组患者的复发率和再住院率。【结果】(1)治疗后,2组患者血清OC、PINP、β-CTX以及P水平均明显改善(P<0.05),且观察组在改善血清OC、PINP、β-CTX以及P水平方面明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的HbA1c水平均明显改善(P<0.05),且治疗组在改善HbA1c水平方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的VAS、HAMA及DSQL评分均明显改善(P<0.05),且治疗组在改善VAS、HAMA及DSQL评分方面明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗组总有效率为88.57%(31/35),对照组为68.57%(24/35)。治疗组疗效优于对照组,差异有统计学意义(P<0.05)。(5)治疗组的复发情况明显少于对照组,差异有统计学意义(P<0.05)。(6)2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】培元养心针灸法联合骨补丸治疗T2DOP,能明显减轻T2DOP患者的疼痛与焦虑症状,改善骨代谢生化指标,从而提高患者的生存质量,增加治疗有效率,并降低复发率和短期内再次住院率,临床疗效显著。
Objective To observe the clinical effect of Peiyuan Yangxin(cultivating vital essence and nourishing heart)acupuncture and moxibustion method combined with Gubu Pills in the treatment of type 2 diabetes mellitus complicated with osteoporosis(T2DOP).Methods A total of 70 patients with T2DOP were randomly divided into treatment group and control group,with 35 cases in each group.The control group was treated with conventional hypoglycemic and calcium supplementation.On the basis of the control group,the treatment group was treated with Peiyuan Yangxin acupuncture and moxibustion method combined with Gubu Pills for eight weeks.After two months of treatment,the clinical efficacy of the two groups was evaluated,and the changes of serum osteocalcin(OC),total type 1 collagen amino acid extension peptide(PINP),β-collagen special sequence(β-CTX),inorganic phosphorus(P)and glycosylated hemoglobin(HbA1c)were observed before and after treatment.The changes of pain Visual Analogue Scale(VAS),Hamilton anxiety scale(HAMA)and diabetes specific quality of life scale(DSQL)scores were compared before and after treatment between the two groups.The safety and adverse reactions of the two groups were evaluated,and the recurrence rate and rehospitalization rate of the two groups were counted.Results(1)After treatment,the serum OC,PINP,β-CTX and P levels of patients in the two groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving serum OC,PINP,β-CTX and P levels,with a statistically significant difference(P<0.05).(2)After treatment,the HbA1c level of patients in both groups was significantly improved(P<0.05),and the treatment group was significantly superior to the control group in improving HbA1c level,with statistically significant differences(P<0.05).(3)After treatment,the VAS,HAMA and DSQL scores of patients in the two groups were significantly improved(P<0.05),and the treatment group was significantly superior to the control group in improving VAS,HAMA
作者
郝梓君
老锦雄
王超轶
许卓康
HAO Zi-Jun;LAO Jin-Xiong;WANG Chao-Yi;XU Zhuo-Kang(The Eighth Clinical Medical School of Guangzhou University of Chinese Medicine,Foshan 528000 Guangdong,China;Foshan Hospital of Traditional Chinese Medicine,Foshan 528000 Guangdong,China;Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2024年第9期2374-2380,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局科研资助项目(编号:202204282125375600)
广东省名中医传承工作室建设项目(编号:粤中医办函[2023]108号)
佛山市“十四五”中医重点专科、特色专科和专病建设项目(编号:佛卫函[2020]15号)
佛山市卫生健康局医学科研项目(编号:20220459)。
关键词
2型糖尿病合并骨质疏松症
培元养心法
针灸
骨补丸
复发率
住院率
生存质量
临床观察
type 2 diabetes mellitus combined with osteoporosis
Peiyuan Yangxin method
acupuncture and moxibustion
Gubu Pills
recurrence rate
rehospitalization rate
quality of life
clinical observation
