摘要
脂肪组织不仅是重要的内分泌器官,也是一种区域性免疫器官,其内的脂肪源性间充质干细胞(ADSCs)是近年来再生医学和脂肪移植领域的热点。然而区域免疫稳态及代谢的失衡会通过代谢重编程等机制引起脂肪组织功能变化,使不同部位和个体来源的脂肪细胞存在差异。部位和个体因素对脂肪组织及其间充质干细胞的影响一直是整形外科医生关注的热点,但这一领域仍存在较大争议,限制了脂肪和ADSCs的临床应用。该文对比了人体不同部位脂肪组织差异,并分析了不同个体因素对脂肪组织功能的影响、可能原因和代谢重编程机制,为更好地探究脂肪代谢功能和ADSCs的临床应用提供参考。
Adipose tissue is not only an important endocrine organ but also a regional immune system.Adipose derived mesenchymal stem cells(ADSCs)are hot spots in regenerative medicine and fat transplantation in recent years.However,the imbalance of regional immune homeostasis and metabolism may effect adipose tissue function through metabolic reprogramming and other mechanisms,resulting in differences in adipocytes from various parts and individuals.Plastic surgeons have always been concerning on the best donor site and individual of fat harvest,but there are still major controversies in this area,limiting the clinical application of adipose and ADSCs.This paper compared the differences of adipose tissue in different parts of the human body,analyzed the effects of different individual factors on adipose tissue function,possible reasons and metabolic reprogramming mechanism,and provided a reference for better exploration of fat metabolism function and clinical application of ADSCs.
作者
岳强
刘立强
Yue Qiang;Liu Liqiang(Perineal Reconstructive and Gender Affirmation Surgery Department,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Bejing 100144,China)
出处
《中华整形外科杂志》
CSCD
北大核心
2024年第8期917-923,共7页
Chinese Journal of Plastic Surgery
基金
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-052)
关键词
脂肪组织
脂肪源性间充质干细胞
肥胖
细胞功能
代谢重编程
Adipose tissue
Adipose-derived mesenchymal stem cells
Obesity
Cell function
Metabolic reprogramming
