摘要
载药微球TACE(DEB-TACE)是应用可加载药物的微球作为栓塞剂,不仅可以永久性栓塞靶血管,而且其加载的化疗药物可缓慢释放,持续作用于靶病灶。近年来,DEB-TACE在肝癌各期的临床治疗中均显示出其重要的作用。对于早期肝癌,DEB-TACE可作为长径>3 cm、为无法外科切除或消融的富血供肝癌的替代疗法,也可作为肝移植前的桥接治疗。对于早期的大肝癌及有潜在根治机会的中期肝癌,DEB-TACE可快速缩小肿瘤活性区域,后续联合消融治疗有望使患者获得根治。对于不可根治的中晚期肝癌,DEB-TACE联合靶向及免疫药物,三者优势互补,可加强短期疗效、延长患者的生存期。精准DEB-TACE联合HAIC治疗,有望成为中晚期肝癌患者介入治疗的新手段。
Drug-eluting beads transarterial chemoembolization(DEB-TACE)is a technique that uses drug-loading microspheres as the embolization agents in performing TACE.These microspheres can not only cause a permanent embolization of targeted blood vessels but also release the loaded chemotherapy drugs slowly,producing a sustained therapeutic effect on the targeted lesions.For recent years,DEB-TACE has demonstrated that it carries important role in the clinical treatment of all stages of hepatocellular carcinoma(HCC).For early-stage HCC,DEB-TACE can be used as an alternative therapy to surgery for the treatment of>3 cm blood-rich HCC that cannot be surgically removed or ablated.DEB-TACE may also be used as a bridging therapy before liver transplantation.For early-stage large HCC and medium-stage HCC carrying the possibility of potential radical cure,DEB-TACE can rapidly reduce the active tumor volume,and the subsequent combination ablation therapy is expected to radically cure the patient's tumor.For unresectable intermediate-stage and advanced-stage HCC,the combination of DEB-TACE plus targeted and immunotherapeutic agents,which carries the effect of three complementary advantages,can strengthen the short-term efficacy and prolong the survival time of patients.Precision DEB-TACE combined with HAIC treatment is expected to become a new means of interventional therapy for patients with advanced HCC.
作者
吴迪
郑琳
WU Di;ZHENG Lin(Department of Interventional Radiology,Affiliated Cancer Hospital of Zhengzhou University(Henan Provincial Cancer Hospital),Zhengzhou,Henan Province 450008,China)
出处
《介入放射学杂志》
CSCD
北大核心
2024年第8期921-927,共7页
Journal of Interventional Radiology
关键词
肝细胞癌
载药微球
经动脉化疗栓塞术
介入治疗
hepatocellular carcinoma
drug-elutingbead
transarterial chemoembolization
interventional therapy
