摘要
目的探讨某口腔专科医院1例疑似苯磺顺阿曲库铵致过敏性休克患者的治疗过程与流程规范性。方法回顾性分析该例患者的治疗经过,依据《药品不良反应报告与监测管理办法》中的药品不良反应(ADR)关联性评价标准,对过敏性休克与苯磺顺阿曲库铵的关联性进行评价,并总结过敏性休克抢救的规范性措施。结果经关联性评价,考虑为苯磺顺阿曲库铵所致过敏性休克。发生过敏性休克后,立刻予吸氧、补液、予以肾上腺素和氢化可的松等抢救措施进行治疗,患者的血压逐渐恢复正常,当日继续手术,且手术顺利,术后3 d出院,随访期间无不适。结论医护人员应高度重视围术期麻醉用药,避免发生过敏性休克。可通过完善肌肉松弛药与抢救药物的用药选择,加强围术期患者各项生命体征的监护,做好过敏反应的识别、判断、积极救治准备等措施,保障患者用药安全。
Objective To investigate the treatment process and its standardization for a patient with suspected anaphylactic shock induced by cisatracurium besilate in a stomatological hospital.Methods A retrospective analysis was conducted on the patient's treatment process.Based on the adverse drug reaction(ADR)association evaluation criteria in the Adverse Drug Reaction Reporting and Monitoring Management Measures,the association between anaphylactic shock and cisatracurium besilate was evaluated,and standardized measures for rescuing anaphylactic shock were summarized.Results After correlation evaluation,it was considered that the allergic shock was induced by cisatracurium besilate.After experiencing anaphylactic shock,the patient was immediately treated with rescue measures such as oxygen inhalation,fluid replacement,injection of adrenaline and hydrocortisone.The patient's blood pressure gradually returned to normal,and the surgery continued on the same day.The surgery went smoothly and the patient was discharged 3 d after surgery without any discomfort during the follow-up period.Conclusion Medical staff should attach great importance to perioperative anesthesia medication to avoid the occurrence of anaphylactic shock.Measures such as improving the selection of muscle relaxants and rescue drugs,strengthening the monitoring of various vital signs of patients during the perioperative period,identifying and judging allergic reactions,and actively preparing for treatment can be taken to ensure the patient's medication safety.
作者
于竹君
李丹丹
钟思雨
王建莉
YU Zhujun;LI Dandan;ZHONG Siyu;WANG Jianli(State Key Laboratory of Oral Diseases·National Clinical Research Center for Oral Diseases·West China Hospital of Stomatology,Sichuan University,Chengdu,Sichuan,China 610041)
出处
《中国药业》
CAS
2024年第17期138-140,共3页
China Pharmaceuticals
基金
四川大学华西口腔医院软科学研究项目[RD-01-202309]。
关键词
苯磺顺阿曲库铵
过敏性休克
神经肌肉阻滞剂
口腔专科医院
药学监护
cisatracurium besilate
anaphylactic shock
neuromuscular blocking agent
stomatological hospital
pharmaceutical care
