摘要
目的:探讨奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血的临床效果。方法:选取2022年5月—2023年5月习水县人民医院收治的胃溃疡合并胃出血患者90例作为研究对象,按照随机数字表法分为对照组和研究组,每组45例。对照组给予奥美拉唑治疗,研究组在对照组基础上给予铝碳酸镁治疗。比较两组治疗效果、症状消失时间、凝血功能指标、胃肠激素指标。结果:研究组治疗总有效率高于对照组(P=0.036)。研究组反酸、腹胀、腹痛、呕血/黑便症状消失时间均短于对照组(P<0.001)。治疗前,两组D-二聚体、血浆纤维蛋白原(FIB)、凝血酶原时间(PT)比较,差异无统计学意义(P>0.05);治疗后,两组D-二聚体水平低于治疗前,且研究组低于对照组,两组FIB高于治疗前,且研究组高于对照组,两组PT短于治疗前,且研究组短于对照组(P<0.05)。治疗前,两组血清生长抑素(SS)、胃泌素(GAS)水平比较,差异无统计学意义(P>0.05);治疗后,两组SS水平高于治疗前,且研究组高于对照组,两组GAS水平低于治疗前,且研究组低于对照组(P<0.05)。结论:奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血的效果显著,能够减轻患者的临床症状,改善胃肠激素水平,提高止血效果。
Objective:To investigate the clinical effect of omeprazole combined with hydrotalcite in the treatment of gastric ulcer with gastric hemorrhage.Methods:A total of 90 patients with gastric ulcer and gastric hemorrhage admitted to Xishui County People's Hospital from May 2022 to May 2023 were selected as the study subjects.They were divided into control group and study group according to random number table method,with 45 patients in each group.The control group was treated with omeprazole,and the study group was treated with hydrotalcite on the basis of control group.The treatment effect,symptom disappearance time,coagulation function indicators,gastrointestinal hormone indicators and occurrence of adverse reactions in two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group(P=0.036).The disappearance time of acid regurgitation,abdominal distention,abdominal pain,hematemesis/melena symptoms in the study group was shorter than that in the control group(P<0.001).Before treatment,there was no significant difference in D-dimer,plasma fibrinogen(FIB) and prothrombin time(PT) between the two groups(P>0.05).After treatment,the level of D-dimer in the two groups was lower than that before treatment,and the level in the study group was lower than that in the control group;the FIB in the two groups was higher than that before treatment,and the FIB in the study group was higher than that in the control group;the PT in the two groups was shorter than that before treatment,and the PT in the study group was shorter than that in the control group(P<0.05).Before treatment,there was no significant difference in serum somatostatin(SS) and gastrin(GAS) levels between the two groups(P>0.05).After treatment,the level of SS in the two groups was higher than that before treatment,and the level of SS in the study group was higher than that in the control group,while the level of GAS in the two groups was lower than that before treatment,and the level of GAS in the
作者
刘勇
周甜甜
杨登位
Liu Yong;Zhou Tiantian;Yang Dengwei(Xishui County People's Hospital,Zunyi 564600,Guizhou Province,China)
出处
《中国社区医师》
2024年第21期63-65,共3页
Chinese Community Doctors
关键词
奥美拉唑
铝碳酸镁
胃溃疡
胃出血
Omeprazole
Hydrotalcite
Gastric ulcer
Gastric hemorrhage
