摘要
目的探讨动态增强磁共振成像(DCE-MRI)对宫颈癌患者病灶组织分化程度及微血管密度(MVD)的评估价值。方法选取2020年6月至2023年3月该院收治的宫颈癌患者65例作为宫颈癌组,均完善DCE-MRI检查,另选取2021年1月至2023年3月因子宫内膜或膀胱类疾病(膀胱结石、膀胱憩室、膀胱炎症)在该院进行DCE-MRI检查的65例健康宫颈患者作为对照组,以病理检查为金标准,分析DCE-MRI对宫颈癌的诊断效能。采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接法检测两组MVD并进行比较;记录两组DCE-MRI定量参数[容量转移常数(Ktrans)、回流速率常数(Kep)、容积分数(Ve值)及表观扩散系数(ADC)]。根据组织分化程度将宫颈癌组分为低分化组(12例)、中分化组(27例)、高分化组(26例),比较不同组织分化程度宫颈癌患者DCE-MRI定量参数水平。采用Pearson相关分析Ktrans、Kep、Ve值与MVD的相关性,采用Spearman相关分析Ktrans、Kep、Ve值与组织分化程度的相关性。结果DCE-MRI诊断宫颈癌的准确度为86.15%(112/130),灵敏度为83.08%,特异度为89.23%,阳性预测值为88.52%,阴性预测值为84.06%,Kappa值为0.723。宫颈癌组Ktrans、Kep、Ve值及MVD明显高于对照组,ADC明显低于对照组,差异均有统计学意义(P<0.05)。低分化组的Ktrans、Kep、Ve值明显高于中分化组及高分化组,ADC明显低于中分化组及高分化组,差异均有统计学意义(P<0.05)。相较于中分化组,高分化组的Ktrans、Kep、Ve值更低,ADC更高,差异均有统计学意义(P<0.05)。Ktrans、Kep、Ve值与组织分化程度均呈负相关,与MVD呈正相关(P<0.05);ADC与组织分化程度呈正相关,与MVD呈负相关(P<0.05)。结论DCE-MRI对宫颈癌的诊断价值较高,且其定量参数与宫颈癌患者病灶组织分化程度及MVD密切相关,应用DCE-MRI定量参数可较好地评估宫颈癌患者病灶组织分化程度及MVD变化。
Objective To explore the evaluation value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)for differentiation degree of lesion tissues and microvessel density(MVD)in patients with cervical cancer.Methods A total of 65 patients with cervical cancer admitted to the hospital were enrolled in the hospital as cervical cancer group from June 2020 to March 2023,and all completed DCE-MRI examination.A total of 65 patients with healthy cervix who underwent DCE-MRI examination for endometrial or bladder diseases(bladder stones,bladder diverticulum,bladder inflammation)were enrolled as control group from January 2021 to March 2023.Taking pathological examination as the golden standard,the diagnostic efficiency of DCE-MRI in cervical cancer was analyzed.MVD in both groups was analyzed by immunohistochemistry and then compared.DCE-MRI quantitative parameters[volume transfer constant(Ktrans),rate constant(Kep),volume fraction(Ve),apparent diffusion coefficient(ADC)]in both groups were recorded.According to tissue differentiation degree,patients in cervical cancer group were divided into low-differentiation group(12 cases),moderate-differentiation group(27 cases)and high-differentiation group(26 cases).The quantitative parameters of DCE-MRI in cervical cancer patients with different tissue differentiation degree were compared.The relationship between DCE-MRI parameters and differentiation degree of lesion tissues was analyzed by Spearman correlation,the relationship between DCE-MRI parameters and MVD in patients with cervical cancer was analyzed by Pearson.Results The accuracy,sensitivity,specificity,positive predictive value,negative predictive value and Kappa coefficient of DCE-MRI in the diagnosis of cervical cancer were 86.15%,83.08%,89.23%,88.52%,84.06% and 0.723 respectively.Compared with control group,Ktrans,Kep,Ve and MVD were significantly higher,while ADC was significantly lower in cervical cancer group(P<0.05).Ktrans,Kep and Ve in low-differentiation group were significantly higher than those in moder
作者
黄海营
吴露露
洪强
貌志成
李昉
杨睿
HUANG Haiying;WU Lulu;HONG Qiang;MAO Zhicheng;LI Fang;YANG Rui(Magnetic Resonance Room,the First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232007,China;Department of Radiology,the First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232007,China;Department of Gynecology,the First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232007,China)
出处
《检验医学与临床》
CAS
2024年第17期2579-2583,共5页
Laboratory Medicine and Clinic
关键词
宫颈癌
动态增强磁共振成像
组织分化程度
微血管密度
相关性
cervical cancer
dynamic contrast-enhanced magnetic resonance imaging
degree of tissue differentiation
microvessel density
correlation
