摘要
葛根素是从葛根中提取得到的异黄酮类化合物,具有广泛的药理活性,常用于治疗心脑血管疾病、降低血糖血脂、抗癌防癌等。然而葛根素的脂溶性和水溶性差,生物利用率不高。结构修饰是改变药物性质的重要手段之一,糖基化修饰葛根素可以很好地增加其水溶性,从而增大其生物利用率。糖基化的主要方法有生物催化和化学合成,本文综述了葛根素糖基化衍生物的常用合成方法及其研究进展。
Puerarin is an isoflavone compound extracted from pueraria,which has a wide range of pharmacological activities,and is often used in the treatment of cardiovascular,cerebrovascular diseases,reducing blood sugar and lipids,and anti-cancer.However,puerarin has poor fat and water solubility and low bioavailability.Structural modification is one of the important means to change the properties of drugs.Glycosylation modification of puerarin can well increase its water solubility and thus increase its bioavailability.The main methods of glycosylation include biocatalysis and chemical synthesis.In this paper,the common synthesis methods of glycosylated derivatives of puerarin are reviewed.
作者
许贤恩
郑艳蓉
徐洁
马越兴
刘婷
Xu Xian′en;Zheng Yanrong;Xu Jie;Ma Yuexing;Liu Ting(Nanchang Madical College,Nanchang 330052,China)
出处
《山东化工》
CAS
2024年第15期125-127,共3页
Shandong Chemical Industry
基金
江西省卫生健康委科技计划(202310080)
江西省教育厅科学技术研究项目(GJJ2203518)
南昌医学院博士科研启动基金项目(NYB22004)
南昌医学院中药药性变化创新团队(NYTD202202)。
关键词
葛根素
糖基化
结构修饰
合成方法
puerarin
glycosylation
structural modification
synthesis methods
