摘要
目的:探讨体外膈肌起搏(EDP)在有创机械通气患者中的应用效果。方法:选取2022年3月—2023年3月南通市通州区人民医院收治的有创机械通气患者80例为研究对象,随机分成对照组和观察组,各40例。对照组给予常规抗感染、镇静、营养支持以及气道管理干预,观察组在对照组基础上给予EDP治疗。比较两组呼吸力学指标[气道阻力(Raw)、气道峰压(PIP)以及动态顺应性(Cdyn)]、膈肌功能指标、住院期间肺部感染发生率、再插管率、ICU住院时间以及28 d内病死率。结果:治疗前,两组Raw、PIP、Cdyn水平比较,差异无统计学意义(P>0.05);治疗后,两组Raw、PIP水平降低,Cdyn水平升高,观察组Raw、PIP水平低于对照组,Cdyn水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组膈肌厚度、膈肌移动度比较,差异无统计学意义(P>0.05);治疗后,观察组膈肌厚度、膈肌移动度高于治疗前且高于对照组,差异有统计学意义(P<0.05)。观察组肺部感染发生率和再插管率低于对照组,差异有统计学意义(P<0.05);两组ICU住院时间以及28 d病死率比较,差异无统计学意义(P>0.05)。结论:EDP能够提高有创机械通气患者的呼吸功能和膈肌功能,降低肺部感染发生率和再插管率,缩短住院时间。
Objective:To investigate the effect of external diaphragm pacing(EDP)in patients with invasive mechanical ventilation.Methods:A total of eighty patients with invasive mechanical ventilation admitted to Nantong Tongzhou District People's Hospital from March 2022 to March 2023 were selected as the study objects and randomly divided into control group and observation group,with forty patients in each group.The control group was given routine anti-infection,sedation,nutritional support and airway management intervention,and the observation group was given EDP on the basis of the control group.The respiratory parameters[airway resistance(Raw),peak airway pressure(PIP),and dynamic compliance(Cdyn)],diaphragm function parameters,incidence of pulmonary infection during hospitalization,rate of re-intubation,length of ICU stay,and 28-day mortality were compared between the two groups.Results:Before treatment,there was no significant difference in Raw,PIP and Cdyn levels between the two groups(P>0.05);after treatment,the levels of Raw and PIP were decreased and the levels of Cdyn were increased in both groups,the levels of Raw and PIP in observation group were lower than those in control group,and Cdyn was higher than those in control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in diaphragm thickness and diaphragm mobility between the two groups(P>0.05);after treatment,the diaphragm thickness and diaphragm movement in the observation group were higher than those before treatment and higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of pulmonary infection and reintubation rate in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the length of ICU stay and 28-day mortality between the two groups(P>0.05).Conclusion:EDP can improve the respiratory function and diaphragm function of patients with i
作者
宋蓉蓉
Song Rongrong(Department of Intensive Care Unit,Nantong Tongzhou District People's Hospital,Nantong 226300,Jiangsu Province,China)
出处
《中外医药研究》
2024年第22期33-35,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
基金
南通市卫生健康委员会科研课题(编号:MB2020075)。
关键词
体外膈肌起搏
有创机械通气
呼吸功能
External diaphragm pacing
Invasive mechanical ventilation
Respiratory function