摘要
目的 分析咳嗽变异性哮喘(Cough Variant Asthma, CVA)患儿予孟鲁司特与布地奈德用药的效果及肺功能改善作用。方法 随机选取2021年6月—2023年6月安溪县医院收治的80例CVA患儿为研究对象,结合随机数字表分为两组,各40例。对照组予布地奈德单药治疗,观察组予布地奈德、孟鲁司特联合治疗。对比两组的咳嗽症状、肺功能、血清炎症指标以及用药安全性。结果 治疗后,观察组日间及夜间咳嗽症状得分均低于对照组,各项肺功能指标值均高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组血清白细胞介素-6、嗜酸性粒细胞水平均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为10.00%,高于对照组的5.00%,但差异无统计学意义(χ^(2)=0.180,P=0.671)。结论 对CVA患儿予孟鲁司特与布地奈德联合治疗,可更有效缓解其咳嗽症状,改善肺功能,减轻机体炎症反应,且用药安全性较高。
Objective To investigate the effect of montelukast and budesonide on the improvement of lung function in children with cough variant asthma(CVA).Methods A total of 80 children with CVA admitted to Anxi County Hospi-tal from June 2021 to June 2023 were randomly selected as study objects and divided into two groups according to ran-dom number table,with 40 cases in each group.The control group was treated with budesonide monotherapy,and the observation group was treated with budesonide and montelukast.The cough symptoms,lung function,serum inflamma-tion indexes and medication safety were compared between the two groups.Results After treatment,the scores of day-time and nighttime cough symptoms in the observation group were lower than those in the control group,and the lung function indexes were higher than those in the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of serum interleukin-6 and eosinophils in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in the observation group was 10.00%,which was higher than 5.00%in the control group,but the difference was not statistically significant(χ^(2)=0.180,P=0.671).Conclusion The combination of montelukast and budesonide in children with CVA can more effectively relieve their cough symptoms,improve lung function,reduce the body's inflammatory response,and the safety of medication is high.
作者
李巧特
杨燕青
李巧尔
LI Qiaote;YANG Yanqing;LI Qiao'er(Department of Pediatric,Anxi County Hospital,Quanzhou 362400,Fujian,China)
出处
《中外医疗》
2024年第19期118-121,共4页
China & Foreign Medical Treatment
