摘要
目的研究肺癌诊断中运用肿瘤标志物的临床价值。方法非随机选取2021年3月—2022年2月在江苏省徐州市中医院接受检查和治疗的50例肺癌患者作为观察1组,选取同期在本院接受检查和治疗的50例肺部良性病变患者作为观察2组,另选取同期接受健康体检的50名健康人作为对照组。抽取3组研究对象的血液样本进行肿瘤标志物检测,主要包括血清癌胚抗原(Carcinoembryonic Antigen,CEA)、糖类抗原125(Carbohydrate Antigen,CA125)、神经元特性烯醇化酶(Neuron-Specific Enolase,NSE)、细胞角蛋白19片段抗原21-1(Cytokeratin Fragment Antigen 21-1,CYFRA21-1)、鳞状上皮细胞癌抗原(Squamous Cell Carcinoma Anti-gen,SCC),分析上述指标单独及联合检测的诊断效能。结果观察1组与观察2组血清CEA、CA125、NSE、CYFRA21-1、SCC表达水平均高于对照组,差异有统计学意义(P均<0.05);且观察1组上述各项指标(15.45±4.16)ng/mL、(51.74±6.56)U/mL、(26.26±2.52)ng/mL、(9.63±3.24)ng/mL、(3.64±0.21)ng/mL高于观察2组,差异有统计学意义(t=8.123、6.598、8.449、5.817、45.521,P均<0.05)。5项肿瘤标志物联合检测的灵敏度为80.0%,特异度为84.0%,准确度为82.0%,kappa=0.817。结论CEA、CA125、NSE、CYFRA21-1、SCC可作为临床上诊断肺癌的肿瘤标志物,联合检测优势显著。
Objective To study the clinical value of tumor markers in the diagnosis of lung cancer.Methods A total of 50 patients with lung cancer who were examined and treated in Xuzhou Hospital of Traditional Chinese Medicine,Jiangsu Province from March 2021 to February 2022 were non-randomly selected as observation group 1,and 50 pa-tients with benign lung lesions who were examined and treated in our hospital during the same period were selected as observation group 2.Another 50 healthy people who underwent physical examination during the same period were se-lected as the control group.Blood samples of three groups of subjects were selected for tumor marker detection.It mainly includes serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),neuron-specific enolase(NSE),cytokeratin fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma antigen(SCC).The diagnostic effi-cacy of single and combined detection of the above indicators was analyzed.Results The expression levels of serum CEA,CA125,NSE,CYFRA21-1 and SCC in the observation group 1 and the observation group 2 were higher than those in the control group,and the differences were statistically significant(all P<0.05).The above indexes in the ob-servation group 1(15.45±4.16)ng/mL,(51.74±6.56)U/mL,(26.26±2.52)ng/mL,(9.63±3.24)ng/mL,(3.64±0.21)ng/mL were higher than those in the observation group 2,and the differences were statistically significant(t=8.123,6.598,8.449,5.817,45.521,all P<0.05).The sensitivity,specificity and accuracy of combined detection of 5 tumor markers were 80.0%,84.0%,82.0%,kappa=0.817.Conclusion CEA,CA125,NSE,CYFRA21-1 and SCC can be used as tumor markers for clinical diagnosis of lung cancer,and the combined detection has significant advantages.
作者
闫颖
孙前进
耿继儒
YAN Ying;SUN Qianjin;GENG Jiru(Department of Clinical Laboratory,Xuzhou Hospital of Traditional Chinese Medicine,Xuzhou 221000,Jiangsu,China)
出处
《系统医学》
2024年第13期174-177,共4页
Systems Medicine
关键词
肿瘤标志物
肺癌
临床诊断价值
Tumor markers
Lung cancer
Clinical diagnostic value
