摘要
对治疗痿病的古籍验方和名医验案进行挖掘,获得中医治疗痿病的核心组方,并加以筛选与评价,为中医优势病种的新药开发提供示范。通过检索治疗痿病的古籍验方和名医验案中所含方药,建立痿病方药数据库,利用中医传承计算平台对古籍验方和名医验案的用药规律进行挖掘分析;基于网络稳健性中药药效预测平台计算获得古籍验方和名医验案核心组方的干扰分值。在此基础上,将古籍验方、名医验案、计算分析的结果进行综合评判,最终确定聚类获得的核心组方的开发优先等级。结果显示,古籍验方和名医验案用药多倾向于补虚、活血化瘀、清热和解表类,尤以温性和甘味药为主,主要归属脾、肝、肾经。古籍验方和名医验案聚类分析获得的核心组方通过网络稳健性分析显示,古籍验方组合1对疾病网络的扰动作用最强,综合评价显示具有最优的开发潜力。中医治疗痿病均重视脾、肝、肾、肺的调理,补虚的同时辅以清热、活血化瘀和解表类药物,获得的古籍验方组合1提示具有最优的潜在开发价值,形成的“古籍验方-名医验案-计算分析”整合策略可用于中药新药候选处方的筛选。
This study aims to explore and analyze ancient proven prescriptions and famous physician cases for treating impotence,so as to obtain the core prescriptions for traditional Chinese medicine(TCM)treatment of impotence.It further selected and evaluated these core prescriptions to provide a demonstration for the development of new drugs for advantageous diseases treated with TCM.Through the retrieval of ancient proven prescriptions and famous physician cases for treating impotence,a database of prescriptions for treating impotence was established,and the TCM inheritance computational platform was used to explore and analyze the medication patterns of these proven prescriptions and famous physician cases.Based on the TCM efficacy prediction platform of network robustness,the interference scores of core prescriptions in the ancient proven prescriptions and famous physician cases were calculated and analyzed.On this basis,the results of ancient proven prescriptions,famous physician cases,and computational analysis were comprehensively evaluated to determine the development priority level of the core prescriptions obtained through clustering.The results revealed that medicines in the ancient proven prescriptions and famous physician cases primarily aimed at tonifying deficiency,promoting blood circulation,eliminating blood stasis,clearing heat,and resolving external symptoms,with a particular focus on warm-natured and sweet-flavored medicines associated with the spleen,liver,kidney,and lung meridians.The core prescriptions obtained from the clustering analysis of ancient proven prescriptions and famous physician cases indicated that ancient proven prescriptions combination 1 had the most perturbing effect on the disease network as determined by network robustness analysis.A comprehensive evaluation indicated that prescription combination 1 had the most optimal development potential.TCM treatment for impotence focused on regulating the functions of the spleen,liver,kidney,and lung,aiming to tonify deficiency,with heat-cl
作者
李煜
张丰荣
王欢欢
常梦丽
徐核
张毅
唐仕欢
LI Yu;ZHANG Feng-rong;WANG Huan-huan;CHANG Meng-li;XU He;ZHANG Yi;TANG Shi-huan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Bejing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第15期4230-4237,共8页
China Journal of Chinese Materia Medica
基金
中国中医科学院科技创新工程项目(CI2021A03705,CI2023E001TS)
国家重点研发计划项目(2018YFC1704101)。
关键词
网络稳健性
数据挖掘
痿病
古籍验方
名医验案
network robustness
data mining
impotence
ancient proven prescriptions
famous physician cases
