摘要
目的:探讨孕妇孕前体质指数、孕期体质量增加与子代孤独症谱系障碍(autism spectrum disorder,ASD)的关系。方法:选取2023年1月至2023年6月于南京医科大学附属脑科医院儿童心理卫生研究中心门诊就诊的221例ASD患儿作为ASD组,同时社区招募137名正常儿童作为对照组。采用自拟一般情况调查表,由入组儿童父母填写研究对象围产期详细临床资料;使用SPSS 26.0软件进行统计分析,对数据进行χ^(2)检验、多因素Logistic回归分析。结果:患儿母亲孕前低体质量检出率为18.7%(67例),平均孕期增重(14.41±5.88)kg,孕期增重不足检出率为9.8%(35例),孕期增重过高检出率为44.9%(161例);男性与女性儿童之间存在统计学意义(χ^(2)=25.6,P=0.000);孤独症发生率在孕期增重过高组、增重适宜组和增重不足组间存在统计学意义(P均<0.05)。结论:孕期体质量增加过高是子代患ASD的危险因素。
Objective:To explore the relationship between pre-pregnancy body mass index(BMI),gestational weightgain and offspring autism spectrum disorder(ASD).Method:221 children with ASD for outpatient department from January 2023 to June 2023 were enrolled as the ASD group,and 137 children with typical development matched in age and sex were recruited in the community.Using a self-designed general situation questionnaire,filled out by parents of enrolled children to collect detailed clinical data of the study subjects during the perinatal period;SPSS 26.0 statistical software was used and the data were analyzed by chi-square test,and multinomial logistics regression.Results:The detection rate of low body weight before pregnancy was 18.7%(67 cases),with an average weight gain of(14.41±5.88)kg during pregnancy.The detection rate of insufficient weight gain during pregnancy was 9.8%(35 cases),and the detection rate of excessive weight gain during pregnancy was 44.9%(161 cases).There was statistical difference between male and female children(χ^(2)=25.6,P=0.000).There is a difference in the incidence of autism between the overweight group,the appropriate weight gain group,and the underweight group during pregnancy(all P<0.05).Conclusion:Excessive weight gain during pregnancy is a risk factor for ASD in offspring.
作者
吴明磊
胥柯
焦公凯
柯晓燕
WU Ming-lei;XU Ke;JIAO Gong-kai;KE Xiao-yan(The Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210000,China)
出处
《临床精神医学杂志》
CAS
2024年第4期253-256,共4页
Journal of Clinical Psychiatry
基金
南京康复医学中心建设项目(2020)
南京医科大学科技发展基金(NMUB20210227)。
关键词
孕前体质指数
孕期增重
孤独症谱系障碍
autism spectrum disorder
pregnancy weight gain
pre-pregnancy body mass index
