摘要
目的:探讨中耳胆脂瘤患者采用自体移植外耳道后壁重建联合鼓室成形术治疗的临床效果。方法:抽取我院耳鼻咽喉头颈外科2019年6月—2023年6月收治的中耳胆脂瘤患者108例为研究对象,采用随机数表法分为对照组和试验组,各54例。对照组行完壁式乳突切除+鼓室成形术治疗,试验组行自体移植外耳道后壁重建+鼓室成形术治疗。评估两组治疗效果,观察两组炎症因子、听力指标变化情况及并发症发生情况。结果:(1)试验组术后3个月白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平显著低于对照组,差异均有统计学意义(P<0.05);(2)试验组术后3个月0.25~4.0kHz频率下气导听阈水平显著低于对照组,差异均有统计学意义(P<0.05);(3)试验组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);(4)两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论:针对中耳胆脂瘤患者给予自体移植外耳道后壁重建联合鼓室成形术治疗,可改善炎症因子水平,促进听力恢复,提高疗效,且该术式并发症少、安全性高。
Objective:To explore the clinical effect of autologous transplantation of the posterior wall of the external auditory canal combined with tympanoplasty in the treatment of middle ear cholesteatoma patients.Methods:108 patients with middle ear cholesteatoma admitted to the Department of Otolaryngology,Head and Neck Surgery,our hospital from June 2019 to June 2023 were selected as the study subjects.They were randomly divided into a control group and an experimental group,with 54 cases in each group.The control group underwent intact canal wall mastoidectomy with tympanoplasty,while the experimental group underwent autologous transplantation of the posterior wall of the external auditory canal and tympanoplasty.The treatment effects of the two groups were evaluated,observe the changes in inflammatory factors,hearing indicators,and incidence of complications in two groups.Results:(1)The levels of Interleukin-1β(IL-1β),Interleukin-6(IL-6),Interleukin-8(IL-8),Tumor Necrosis Factor-α(TNF-α)in the experimental group were significantly lower than that of the control group 3 months after operation,and the differences were statistically significant(P<0.05).(2)The level of air conduction hearing threshold in the experimental group was significantly lower than that in the control group at a frequency of 0.25~4.0 kHz 3 months after surgery,and the differences were statistically significant(P<0.05).(3)The total effective rate of treatment in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).(4)There was no statistically significant difference in the total incidence of complications between two groups(P>0.05).Conclusion:For patients with middle ear cholesteatoma,autologous transplantation of the posterior wall of the external ear canal combined with tympanoplasty can improve inflammatory cytokine levels,promote hearing recovery,and enhance therapeutic efficacy.This surgical procedure has fewer complications and higher safety.
作者
陈立萍
CHEN Liping(Xiamen Humanity Hospital Affiliated to Fujian Medical University,Xiamen City,Fujian Province 361009)
出处
《医学理论与实践》
2024年第17期2906-2909,共4页
The Journal of Medical Theory and Practice
关键词
中耳胆脂瘤
自体移植外耳道后壁重建
鼓室成形术
效果
Middle ear cholesteatoma
Autologous transplantation for reconstruction of the posterior wall of the external auditory canal
Tympanoplasty
Effect
