摘要
目的分析血清炎症因子、脑源性神经营养因子(BDNF)在双相情感障碍(BD)患者中的水平变化,并分析其与BD临床症状的相关性。方法选取宿州市第二人民医院2021年1月—2023年1月收治的100例BD患者,根据BD病情分为BD发作组(47例)和BD缓解组(53例),另选取同期收治的100例单相抑郁情感障碍患者作为单相组、78例健康体检者作为健康组。采用酶联免疫吸附试验(ELISA)检测并比较4组患者的血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和BDNF水平。比较4组患者血清IL-1β、TNF-α、BDNF水平及汉密顿抑郁量表(HAMD)、贝克-拉范森躁狂量表(BRMS)以及霍普金斯词语学习测验修订版(HVLT-R)评分,采用Pearson分析法分析血清IL-1β、TNF-α及BDNF水平与BD患者临床症状的相关性。结果BD发作组、BD缓解组和单相组患者的发病频率和病程比较差异有统计学意义(P<0.05),其中BD发作组和BD缓解组患者的发病频率及病程均高于单相组,且BD发作组患者的发病频率及病程高于BD缓解组(P<0.05);与健康组相比,单相组、BD发作组和BD缓解组患者血清IL-1β和TNF-α水平显著升高(P<0.05),且BD发作组和BD缓解组患者血清IL-1β和TNF-α水平高于单相组,BD发作组患者血清IL-1β和TNF-α水平高于BD缓解组(P<0.05);与健康组相比,单相组、BD发作组和BD缓解组患者BDNF水平显著降低(P<0.05),且BD发作组和BD缓解组患者BDNF水平低于单相组,BD发作组患者BDNF水平低于BD缓解组(P<0.05);与健康组相比,单相组、BD发作组和BD缓解组患者HAMD和BRMS评分均显著升高(P<0.05),BD发作组和BD缓解组患者BRMS评分高于单相组,BD发作组患者BRMS评分高于BD缓解组(P<0.05),且BD发作组和单相组患者HAMD评分高于BD缓解组,BD发作组患者HAMD评分高于BD缓解组(P<0.05);与健康组相比,单相组、BD发作组和BD缓解组患者HVLT-R评分显著降低(P<0.05),且BD发作组和BD缓解组患者HVLT-R评分低于单
Objective Analyze the level changes of serum inflammatory factors and brain-derived neurotrophic factor(BDNF)in bipolar disorder(BD),and analyze their correlation with clinical symptoms of BD.Methods Select 100 BD patients admitted to our hospital from January 2021 to January 2023,and divide them into BD attack group(47 cases)and BD relief group(53 cases)based on their BD condition.In addition,select 100 single-phase depression and emotional disorder patients admitted during the same period as the single-phase group and 78 healthy examinees as the healthy group.Detection and comparison of serum interleukin-1 levels in four groups of patients using enzyme-linked immunosorbent assay(ELISA)β(IL-1)β)、Tumor necrosis factor-α(TNF)-α)And BDNF level.Compare serum IL-1 levels among four groups of patientsβ、TNF-α、BDNF levels and Hamilton Depression Scale(HAMD),Beck Ravensen Mania Scale(BRMS),and Revised Hopkins Word Learning Test(HVLT-R)scores were analyzed using Pearson analysis to determine serum IL-1 levelsβ、TNF-αThe correlation between BDNF levels and clinical symptoms in BD patients.Results The frequency and course of disease in the BD attack group,BD remission group,and monophasic group were compared,and the difference was statistically significant(P<0.05).Among them,the frequency and course of disease in the BD attack group and BD remission group were higher than those in the monophasic group,and the BD attack group was higher than that in the BD remission group(P<0.05).Compared with the healthy group,the monophasic group,BD attack group,and BD remission group had serum IL-1 levelsβAnd TNF-αThe level significantly increased(P<0.05),and the BD attack group and BD remission group were higher than the monophasic group,while the BD attack group was even higher(P<0.05).Compared with the healthy group,the BDNF levels in the monophasic group,BD attack group,and BD remission group were significantly reduced(P<0.05),and the BD attack group and BD remission group were lower than the monophasic group,while th
作者
王兰兰
沈子童
陈长浩
WANG Lanlan;SHEN Zitong;CHEN Changhao(Department of Psychiatry,Second People's Hospital,Suzhou City,Anhui Suzhou 234000,China)
出处
《中国实验诊断学》
2024年第8期946-950,共5页
Chinese Journal of Laboratory Diagnosis
基金
2020年度安徽省自然科学基金项目(编号:2008085QH407)。
