摘要
手性辅基控制的不对称合成是获取手性化合物的重要方法之一,被广泛应用于医药合成领域。基于目前手性布洛芬合成问题,研究团队发展了经Cu(OTf)2催化羰基α-位不对称芳基化反应制备手性药物(S)-布洛芬的合成新方法,并将研究成果转化为本科综合实验教学,可以帮助学生掌握多步有机合成反应操作,理解不对称合成技术对服务国家需求和维护人民生命健康的重要意义。此外,本文对实验所蕴含的思政元素进行充分挖掘,并将之与实验教学环节深入融合,最终培养学生的科学思维、创新能力、团队合作精神、专业认同感和社会责任感。
Asymmetric synthesis using chiral auxiliary strategy is one of the important methods for the synthesis of chiral compounds,which is widely used in the field of pharmaceutical synthesis.To address the synthetic challenges posed by chiral ibuprofen,we herein reported a new synthetic method to(S)-ibuprofen via the enantioselectiveα-arylation of carbonyls catalyzed by Cu(OTf)2.By transforming the research achievement into the undergraduate comprehensive experiments,we hope the students could master the skill of multistep synthesis,and could understand the importance of asymmetric synthesis technology in serving national needs and maintaining human health.The ideological and political elements are fully explored,and deeply integrated with multi-link experimental teaching.The scientific consideration and innovation,as well as and the teamwork cooperation ability are to be cultivated,and also the identity of chemistry major and social responsibility will be improved for undergraduate students.
作者
陈勃廷
张振凯
黄玲林
贺凤开
黄毅勇
Chen Boting;Zhang Zhenkai;Huang Linglin;He Fengkai;Huang Yiyong(Department of Chemistry,School of Chemistry,Chemical Engineering and Life Science,Wuhan University of Technology,Wuhan,430070;State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan,430070)
出处
《化学通报》
CAS
CSCD
北大核心
2024年第8期992-998,共7页
Chemistry
基金
国家自然科学基金项目(22301229,22072111,22372128)资助。
关键词
不对称合成
手性辅基
课程思政
实验教学
Asymmetric synthesis
Chiral auxiliary
Ideology and politics course
Experimental teaching
