摘要
鲍曼不动杆菌(AB)为革兰阴性菌,亦是导致住院患者发生呼吸道、尿路、创口等部位感染的重要条件致病菌。如AB生物被膜(BF)形成,可使其对诸多抗菌药物产生抗药性,导致泛耐药AB出现,从而使治疗更加棘手。近年来,中药单体凭借抗药性低、副作用少等优势,逐渐被用于AB感染性疾病治疗中。中药单体除可具有杀菌作用外,还可能通过细菌黏附相关基因的表达、改变BF通透性等作用而发挥抗BF效应。本文通过梳理国内外权威文献,总结了AB的BF形成机制及中药单体对其的干预作用,旨在充分揭示中药单体对AB的BF形成的干预机制,为AB感染的中药治疗提供充足的依据。
Acinetobacter baumannii(AB)is a Gram negative bacterium and an important opportunistic pathogen that causes respiratory,urinary,and wound infections in hospitalized patients.The formation of AB biofilm(BF)can make it resistant to many antibiotics,leading to the emergence of pan resistant AB and making treatment more challenging.In recent years,traditional Chinese medicine monomer has been gradually used in the treatment of AB infectious diseases due to its low drug resistance and few side effects.In addition to having bactericidal effects,traditional Chinese medicine monomers may also exert anti BF effects by reducing the expression of bacterial adhesion related genes and altering BF permeability.This article summarizes the mechanism of BF formation in AB and the intervention effect of traditional Chinese medicine monomers on it by reviewing authoritative literature at home and abroad,aiming to fully reveal the intervention mechanism of traditional Chinese medicine monomers on BF formation in AB,and provide sufficient basis for the traditional Chinese medicine treatment of AB infection.
作者
费露颍
钱义明
胡冠宇
沙媛媛
吴笑阳
郭健
FEI Luying;QIAN Yiming;HU Guanyu;SHA Yuanyuan;WU Xiaoyang;GUO Jian(Departmentof Emergency,Yueyang Hospital of Integrated Chinese and Western Medicine,Shanghai University of Traditional ChineseMedicine,Shanghai200437,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2024年第9期1109-1111,共3页
Journal of Pathogen Biology
基金
上海市科学技术委员会科技计划项目(No.23ZR1464200)。
关键词
鲍曼不动杆菌
生物被膜
调控机制
中药单体
综述
Acinetobacter baumanni
biofilm
regulatory mechanisms
Traditional Chinese medicine monomer
review
