摘要
目的探讨中等强度有氧运动与颈动脉轻度狭窄人群脑血流调节功能的相关性。方法采用回顾性研究的方法,选取2022年7月至2023年11月大连理工大学附属中心医院单侧颈动脉轻度狭窄、同时进行中等强度有氧运动1年以上人群30例为研究组即运动组,选取年龄、性别等因素相匹配无运动习惯的单侧颈动脉轻度狭窄人群30例为对照组即非运动组;两组患者均进行经颅多普勒超声(TCD)检查,并进行卧立位试验、屏气试验和换气试验,计算卧立位"w"波出现率、卧立位"w"波斜率、屏气及换气前后搏动指数(PI)变化率、阻力指数(RI)变化率、屏气指数(BHI)以及换气前后脑血流速度变化率,同时计算卧立位血压及心率差,通过统计学分析评估进行中等强度有氧运动与颈动脉轻度狭窄人群的脑血流调节功能的相关性;将研究组人群的运动年限与BHI进行相关性分析,探索运动年限与脑血管反应性的关系。结果研究组人群的卧立位"w"波出现率、下降支斜率、上升支斜率均大于对照组[93.3%(28/30)比86.7%(26/30)、2.27±1.14比1.28±0.23、2.67±0.63比1.41±0.69],差异有统计学意义(P<0.05);研究组屏气及换气前后PI及RI变化率均大于对照组(21.23±7.67比13.89±9.67、14.62±6.63比11.17±1.78和26.26±12.46比18.36±12.13、14.91±4.91比10.83±2.35),换气前后平均脑血流速度大于对照组[(31.26±4.92)cm/s比(24.89±6.34)cm/s],差异有统计学意义(P<0.01);研究组人群运动年限与屏气指数呈负相关。结论中等强度运动与颈动脉轻度狭窄人群的脑血流调节功能相关;运动年限与脑血流调节功能呈负相关;脑血流调节功能受损可能是颈动脉狭窄人群发生卒中预后不良的潜在机制之一。
Objective:To investigate the correlation between moderate intensity aerobic exercise and cerebral blood flow regulation in patients with mild carotid artery stenosis.Methods:A retrospective study was conducted to select 30 cases of patients with unilateral mild carotid artery stenosis and moderate intensity aerobic exercise for more than 1 year in the Central Hospital of Dalian University of Technology from July 2022 to November 2023 as the exercise group(study group),and 30 cases of patients with unilateral mild carotid artery stenosis without exercise habits matched by age,gender and other factors as the non-exercise group(control group).Transcranial Doppler ultrasound(TCD)examination was performed in both groups,and the recumbent-upright-test,breath holding test and breath exchange test were performed to calculate the occurrence rate of"w"wave in recumbent-upright position,the slope of"w"wave in recubitus position,the change rate of pulse index(PI)before and after breath holding,resistance index(RI),breath holding index(BHI),and cerebral blood flow velocity before and after breath exchange.The blood pressure and heart rate difference in the recumbent-upright position were calculated,and the correlation between moderate intensity aerobic exercise and cerebral blood flow regulation function in patients with mild carotid artery stenosis was evaluated by statistical analysis.The correlation analysis between the exercise years and BHI in the study group was carried out to explore the relationship between the exercise years and cerebrovascular reactivity.Results:The occurrence rate and slope of"w"wave in the study group were higher than those in the control group:93.3%(28/30)vs.86.7%(26/30),2.27±1.14 vs.1.28±0.23,2.67±0.63 vs.1.41±0.69,there were statistically significant(P<0.05).The change rates of PI and RI before and after breath holding and ventilation in the study group were higher than those in the control group:21.23±7.67 vs.13.89±9.67,14.62±6.63 vs.11.17±1.78 and 26.26±12.46 vs.18.36±12.13,14.91±4
作者
潘心
张亚楠
马舒贝
刘书含
隋晓雯
刘海斌
李福荣
李祖圣
赵红玲
Pan Xin;Zhang Yanan;Ma Shubei;Liu Shuhan;Sui Xiaowen;Liu Haibin;Li Furong;Li Zusheng;Zhao Hongling(Department of Neurology,Central Hospital of Dalian University of Technology,Dalian 116033,China;Stroke Center,Central Hospital of Dalian University of Technology,Dalian 116033,China;School of Biomedical Engineering,Faculty of Medicine,Dalian University of Technology,Dalian 116024,China)
出处
《中国医师进修杂志》
2024年第8期694-699,共6页
Chinese Journal of Postgraduates of Medicine
基金
生命健康领域指导计划项目(医工交叉)(2022ZXYG03)。
关键词
颈动脉狭窄
中等强度有氧运动
脑血流调节
经颅多普勒超声
Carotid stenosis
Moderate intensity aerobic exercise
Cerebral blood flow regulation
Transcranial Doppler ultrasound
