摘要
目的探究原发性肾病综合征儿童血清Apelin-13、FOXO1表达水平及其临床意义。方法选取2019年1月至2022年12月在本院收治的183例原发性肾病综合征儿童作为研究组。另选取同时期在本院体检的185名体检健康的儿童作为对照组,苏木精-伊红(ELISA)法检测血清Apelin-13、FOX-O1水平;采用Pearson法分析Apelin-13、FOXO1水平与血脂指标的关系;使用受试者工作特征(ROC)曲线分析Apelin-13、FOXO1对原发性肾病综合征的诊断价值;多因素Logistic回归分析影响原发性肾病综合征发生的危险因素。结果与对照组比较,研究组患儿血清Apelin-13水平降低,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(apo)B、FOXO1水平升高(P<0.05);与研究组治疗前比较,治疗后血清Apelin-13水平升高,TG、TC、LDL-C、apoB、FOXO1水平降低(P<0.05);Pearson相关性分析表明,原发性肾病综合征患儿血清Apelin-13与TG、TC、LDL-C、apoB均呈负相关,FOXO1与TG、TC、LDL-C、apoB均呈正相关(P<0.05);ROC曲线分析表明,Apelin-13、FOXO1诊断原发性肾病综合征发生的曲线下面积(AUC)为0.795、0.734,二者联合诊断的AUC为0.920;多因素Logistic回归分析显示,Apelin-13与FOX-O1是影响原发性肾病综合征发生的危险因素。结论原发性肾病综合征儿童血清Apelin-13呈低表达、FOXO1呈高表达,二者与血脂水平有关,并且对原发性肾病综合征具有一定的诊断价值。
Objective To investigate the serum Apelin-13 and forkhead box transcription factor O subfamily 1(FOXO1)expression levels and their clinical significance in children with primary nephrotic syndrome.Methods From January 2019 to December 2022,183 children with primary nephrotic syndrome accepted by the department of our hospital were gathered as the study group.In addition,185 physically healthy children who had their medical checkups in this hospital during the same period were set as the control group.ELISA method was performed to detect serum Apelin-13 and FOXO1 levels;Pearson method was performed to analyze the relationship between Apelin-13,FOXO1 levels,and blood lipids indicators.The receiver operating characteristic(ROC)curve was performed to analyze the diagnostic value of Apelin-13 and FOXO1 in children with primary nephrotic syndrome;multivariate Logistic regression was performed to analyze the risk factors affecting the occurrence of primary nephrotic syndrome in children.Results Compared with the control group,the level of serum Apelin-13 of the children in the study group was lower,and the level of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),apolipoprotein(apo)B and FOXO1 was higher(P<0.05).Compared with the study group before treatment,the level of serum Apelin-13 was notably higher after treatment,and the level of TG,TC,LDL-C,apoB and FOXO1 was lower(P<0.05).Pearson correlation analysis showed that serum Apelin-13 was negatively correlated with TG,TC,LDL-C,and apoB in children with primary nephrotic syndrome,and FOXO1 was positively correlated with TG,TC,LDL-C,and apoB(P<0.05).ROC curve analysis showed that the area under the cure AUC of Apelin-13 and FOXO1 in the diagnosis of primary nephrotic syndrome were 0.795 and 0.734,and the(AUC)of the two combined diagnosis was 0.920;Multivariate Logistic regression analysis showed that Apelin-13 and FOXO1 were risk factors for the occurrence of primary nephrotic syndrome.Conclusion Serum Apelin-13 in children with primary
作者
陆彩霞
钟余楷
刘健
吴亲芳
何欢
刘兴元
Lu Caixia;Zhong Yukai;Liu Jian;Wu Qinfang;He Huan;Liu Xingyuan(Department of Pediatrics Kangjiang Hospital,Yangpu District,Shanghai 200093,China;不详)
出处
《山西医药杂志》
CAS
2024年第11期813-818,共6页
Shanxi Medical Journal
