摘要
自噬可以通过吞噬并降解细胞内的蛋白、细胞器以及其他胞质成分,实现细胞器的更新和满足自身的代谢需要。生理情况下,自噬有利于维持细胞的稳态,而自噬紊乱是多种泌尿系肿瘤发生发展的关键机制。自噬在肿瘤形成的早期作为其抑制因素,而晚期为癌细胞提供营养物质促进生长。目前大量研究表明,细胞自噬在泌尿系肿瘤的发生发展中发挥重要作用,同时自噬对肿瘤治疗有细胞保护性和细胞毒性的双重影响,因此通过调控自噬能提高其治愈率,为泌尿系肿瘤提供新的治疗方向。本文主要总结了自噬的发生机制以及对泌尿系肿瘤发生发展的作用和潜在的治疗价值,致力于将自噬调节和现有的泌尿系肿瘤治疗方式结合有助于增加抗肿瘤治疗效果。
Autophagy can renew organelles and meet its own metabolic needs by engulfing and degrading intracellular proteins,organelles,and other cytoplasmic components.Under physiological conditions,autophagy is beneficial for maintaining cellular homeostasis,whereas autophagy disorders are a key mechanism in the development of a variety of urological tumors.Autophagy acts as an inhibitory factor for tumors in the early stage of tumor formation,while it provides nutrients for cancer cells to promote growth in the late stage.A large number of studies have shown that cellular autophagy plays an important role in the development of urological tumors,and at the same time,autophagy has both cytoprotective and cytotoxic effects on tumor therapy,so that regulating autophagy can improve the cure rate and provide a new therapeutic direction for urological tumors.In this paper,we summarize the mechanism of cellular autophagy and its role and potential therapeutic value in the development of urological tumors,and the combination of autophagy regulation and existing therapeutic modalities of urological tumors is likely to become the mainstream of the treatment of urological tumors in the future.
作者
向阳
文周
杨萌
袁东波
吕涵
陈宗裕
朱建国
Xiang Yang;Wen Zhou;Yang Meng;Yuan Dongbo;Lyu Han;Chen Zongyu;Zhu Jianguo(Department of Urology,Guizhou Provincial People′s Hospital,Guiyang 550000,China;Zunyi Medical University,Zunyi 563000,China;Pediatric Surgery,Guizhou Branch of Shanghai Children′s Medical Center,Guiyang 550002,China;Guizhou Medical University,Guiyang 550000,China)
出处
《中国医药》
2024年第9期1421-1425,共5页
China Medicine
基金
国家自然科学基金(82160551、82303301)。
关键词
泌尿系肿瘤
自噬
耐药性
前列腺癌
肾癌
膀胱癌
Urologic tumors
Autophagy
Drug resistance
Prostate cancer
Kidney cancer
Bladder cancer
