摘要
基于美国疫苗不良反应报告系统(vaccine adverse event reporting system,VAERS)的数据,对Menactra、Menveo、MenQuadfi、Trumenba和Bexsero这5种上市脑膜炎疫苗接种相关不良反应(adverse event,AE)进行综合分析与评价。截至2023年3月31日,从数据库中分别检索下载5种疫苗相关不良反应数据,采用整合本体学(combinatorial ontology-based detection of vaccine adverse events method,CODAE)方法挖掘筛选出共计94种有统计学意义的不良反应,其中23种属于严重不良反应;通过制定本体逻辑关系上的不良反应图谱,显示行为和神经学病变是最为富集的不良反应类别;通过汇总死亡案例的临床信息,统计分析可能影响死亡发生的接种过程变量,发现接种者年龄等变量对死亡发生有一定的影响,然而可用数据信息相对较少,相关结果有待进一步论证。针对不良反应的分析与评价表明,当前上市的5种脑膜炎疫苗是相对安全的,对于特定严重不良反应与疫苗接种以及接种者自身状况之间的确切关系值得在未来的工作中进行更为深入的研究。
This study aims to analyze and evaluate adverse event(AE)associated with five licensed meningitis vaccines(Menactra,Menveo,MenQuadfi,Trumenba and Bexsero)based on data from vaccine adverse event reporting system(VAERS).As of March 31,2023,the AE data associated Menactra,Menveo,MenQuadfi,Trumenba,and Bexsero were retrieved from VAERS database respectively.A total of 94 statistically significant adverse events were identified using the combinatorial ontology-based detection of vaccine adverse events method(CODAE),including 23 serious adverse events.By mapping out the ontology-based AE profiles,we showed that these significant AEs were clustered in the behavioral and neurological conditions.In addition,a statistical analysis with detailed information in death case reports was used to ascertain the major variables that might affect the occurrence of death AE.We found that variables such as the age of the vaccinated person had a certain impact on the occurrence of death.However,the available data was relatively limited,and the relevant results needed further verification.The analysis and evaluation of adverse events indicated that the five currently marketed meningitis vaccines were relatively safe.The exact relationship between specific serious adverse events,vaccination,and the condition of the vaccinated person deserved further in-depth research in future work.
作者
张雪
苏俊
杨秋月
谢江安
ZHANG Xue;SU Jun;YANG Qiuyue;XIE Jiangan(School of Life Health Information Science and Engineering,Chongqing University of Posts and Telecommunications,Chongqing 400065,P.R.China)
出处
《重庆邮电大学学报（自然科学版）》
CSCD
北大核心
2024年第4期697-706,共10页
Journal of Chongqing University of Posts and Telecommunications(Natural Science Edition)
基金
重庆市教育委员会科学技术研究项目(KJZD-K202000603)
国家自然科学基金青年基金项目(61801067)。
