摘要
目的探讨多西环素联合硫酸羟氯治疗玫瑰痤疮的临床效果安全性。方法选取2023年2月至2024年5月在鹤山市中医院接受治疗的70例玫瑰痤疮患者,按治疗方法不同分为对照组(n=31)和联合组(n=39)。对照组外用夫西地酸乳膏联合口服多西环素,联合组外用夫西地酸乳膏联合口服多西环素和羟氯喹。观察两组患者治疗效果、皮损症状(红斑、丘疹、脓疱、瘙痒、毛细血管扩张)改善情况;记录两组患者治疗期间不良反应(恶心、头晕头痛、面部刺痛潮红)发生情况。结果治疗后,联合组面部皮损症状评分均低于对照组,差异有统计学意义(P<0.05)。联合组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应比较差异无统计学意义(P>0.05)。结论夫西地酸乳膏、多西环素联合硫酸羟氯治疗玫瑰痤疮能够有效改善玫瑰痤疮患者皮损症状,疗效显著、安全性好。
Objective To investigate the clinical effificacy and safety of doxycycline combined with hydroxychloroquine sulfate in the treatment of rosacea.Methods A total of 70 patients with rosacea treated in Heshan Hospital of Chinese Medicine from February 2023 to May 2024 were selected,they were divided into control group(n=31)and combination group(n=39)according to different treatment methods.The patients in control group receiving fusidic acid cream combined with doxycycline orally,the combination group received topical fusidic acid cream combined with doxycycline and hydroxychloroquine orally.The therapeutic effect and improvement of skin lesion symptoms(erythema,papule,pustule,pruritus,telangiectasia)were observed in the two groups.The occurrence of adverse reactions(nausea,dizziness,headache,facial tingling and flflushing)during treatment was recorded in the two groups.Results After treatment,the facial skin lesion symptom scores in the combination group were lower than those in the control group,and the difference was statistically signifificant(P<0.05).The effective rate of the combined treatment group was higher than that of the control group,and the difference was statistically signifificant(P<0.05).During the treatment period,there was no statistically significant difference in adverse reactions between the two groups of patients(P>0.05).Conclusions Fusidic acid cream and doxycycline combined with hydroxychloroquine sulfate can effectively improve the symptoms of skin lesions in rosacea patients,with signifificant effificacy and high safety.
作者
黄汉飞
宋丽华
周慧
冯子来
陈伟英
HUANG Hanfei;SONG Lihua;ZHOU Hui;FENG Zilai;CHEN Weiying(Dermatology,Heshan Hospital of Chinese Medicine,Guangdong Province,529700,China;Dermatology,Heshan City chronic disease prevention station,Guangdong Province,529700,China)
出处
《中国医疗美容》
2024年第7期20-23,共4页
China Medical Cosmetology
关键词
玫瑰痤疮
硫酸羟氯喹
多西环素
rosacea
hydroxychloroquine sulfate
doxycycline
