摘要
在卵巢癌的治疗过程中,肿瘤细胞往往会对化疗药物产生耐药性,导致治疗效果减弱或消失。因此,抗血管生成治疗作为一种重要的维持治疗手段,通过不同的机制与其他治疗方法协同作用,可以有效减慢疾病进展速度。外泌体是由活细胞分泌的细胞外囊泡,携带着多种遗传物质,在肿瘤微环境中起着细胞通信的重要作用。研究发现,肿瘤细胞及其他细胞来源的外泌体可以通过释放非编码RNA、蛋白质等遗传物质影响血管生成及其他肿瘤相关过程。利用外泌体靶向特定蛋白或作为包裹治疗剂的外源性载体,已经成为卵巢癌抗血管生成治疗的重要策略。综述外泌体对卵巢癌血管生成的调控机制,以及其作为抗血管生成剂的作用潜力,以期为新的治疗方法提供理论依据。
In the treatment of ovarian cancer,tumor cells often become resistant to chemotherapy drugs,leading to weakened or ineffective treatment outcomes.Therefore,anti-angiogenesis therapy serves as an important adjunctive treatment,can effectively slow disease progression by synergizing with other treatment modalities through various mechanisms.Exosomes,extracellular vesicles secreted by living cells,carry a variety of genetic materials and play crucial roles in cell communication within the tumor microenvironment.Studies have shown that exosomes derived from tumor cells and other cell sources can influence angiogenesis and other tumor-related processes by releasing non-coding RNAs,proteins,and other genetic materials.Utilizing exosomes to target specific proteins or as exogenous carriers for encapsulate therapeutic agents has become an important strategy for anti-angiogenesis therapy in ovarian cancer.This review summarized the regulatory mechanism of exosomes on angiogenesis in ovarian cancer and it also explores the potential of exosomes as anti-angiogenic agents,providing a theoretical basis for new treatment methods.
作者
张静怡
刘东哲
陈秀慧
ZHANG Jing-yi;LIU Dong-zhe;CHEN Xiu-hui(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China;Department of Hematology and Oncology,Shenzhen University General Hospital,Shenzhen 518055,Guangdong Province,China)
出处
《国际妇产科学杂志》
CAS
2024年第4期370-374,共5页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(81802592)
中国博士后科学基金会基金(2018M641854)。
关键词
外泌体
卵巢肿瘤
新生血管化
治疗
肿瘤微环境
Exosomes
Ovarian neoplasms
Neovascularization
Therapy
Tumor microenvironment
