摘要
目的分析滨州市某医院妇科自然就诊患者人乳头瘤病毒(human papillomavirus,HPV)基因型分布及HPV感染例数,为当地宫颈癌防治提供参考。方法统计分析2020年1月—2022年12月妇科自然就诊患者HPV基因亚型及单一和多重感染率。结果2020——2022年滨州市某医院妇科自然就诊患者进行HPV基因型检测,三年共检测HPV 22580例,共检出HPV阳性者4458例,阳性率为19.86%;单一HPV基因型感染者3301例,阳性率14.62%,多重HPV感染者1184例,阳性率5.24%。对2020——2022年HPV感染患者进行HPV基因型统计分析,结果显示:高危型HPV(HR-HPV)前五位是HPV 52型、HPV 16型、HPV 58型、HPV 51型、HPV 68型,低危型HPV感染第一位为HPV 42型;HPV感染最少的基因型是HPV 83型。年龄方面,HPV感染者以21~60岁年龄段人群为主,≤20岁HPV感染者126例,最小年龄者16岁;>60岁HPV感染者153例,最大年龄为87岁,此两年龄组HPV多重感染率均高出21~60岁年龄组。结论本地患者HPV感染者以HPV 52型最多,其次为HPV 16型。HPV感染以单一型为主,多重感染者比例也不容忽视。HPV基因型检测是宫颈癌筛查的重要手段。
Objective To analyze the genotype distribution and infection characteristics of human papillomavirus(HPV)in gynecological patients in Binzhou People′s Hospital,and provide references for local cervical cancer prevention and treatment.Methods Human papillomavirus(HPV)genotypes,single and multiple infection rates were statistically analyzed in gynecological patients from January 2020 to December 2022.Results In 2020,2021 and 2022,a total of 22580 HPV-positive cases were detected,and a total of 4458 HPV-positive cases were detected,with the positive rate 19.86%.The positive rate was 14.62% in 3301 patients with single HPV genotype and 5.24% in 1184 patients with multiple HPV genotype.Statistical analysis of HPV genotypes of patients infected in 2020,2021 and 2022 showed that:the top five types of high-risk HPV(HR-HPV)were HPV52,HPV16,HPV58,HPV51,and HPV68,while the first type of low-risk HPV infection was HPV42.The genotype with the least amount of HPV infection was HPV83.In terms of age,from 2020 to 2022,the majority of HPV infected people were 21~60 years old,126 cases of HPV infected people were≤20 years old,and the youngest age was 16 years old.There were 153 cases of HPV infection in>60 years old,and the oldest age was 87 years old.The multiple infection rate of HPV in these two age groups was higher than that in 21~-60 years old.Conclusion HPV52 was the most common infection in local patients,followed by HPV16.HPV infection was mainly single type,and the proportion of multiple infection could not be ignored.HPV genotype detection is an important means of cervical cancer screening.
作者
胡建华
董雅萌
吴肖婕
HU Jianhua;DONG Yameng;WU Xiaojie(Central Laboratory,Binzhou People's Hospital,Binzhou 256610,Shandong,P.R.China;Nursing Department,Binzhou People's Hospital,Binzhou 256610,Shandong,P.R.China)
出处
《滨州医学院学报》
2024年第4期277-280,共4页
Journal of Binzhou Medical University
关键词
人乳头瘤病毒
基因型
感染
宫颈癌
human papillomavirus
genotype
infection
cervical cancer
