摘要
目的分析加味苍术泄浊饮对高尿酸血症患者尿酸(UA)及血脂水平的影响。方法选取医院2021年3月至2022年12月收治的高尿酸血症患者100例,随机分为观察组和对照组,各50例。两组患者均予常规生活干预及口服别嘌醇缓释胶囊,观察组患者加用加味苍术泄浊饮。两组均治疗4周。结果观察组总有效率为94.00%,显著高于对照组78.00%(P<0.05)。与对照组比较,观察组患者治疗后的中医证候(关节疼痛、关节肿胀、活动受限、身寒/身热)积分,UA及钾离子、钠离子水平,总胆固醇、甘油三酯水平均显著降低(P<0.05);观察组与对照组不良反应发生率相当(12.00%比6.00%,P>0.05)。结论与单用别嘌醇比较,联用加味苍术泄浊饮治疗高尿酸血症可进一步改善患者相关临床症状,调节UA、电解质水平,降低血脂水平。
Objective To analyze the effects of modified Cangzhu Xiezhuo Drink on the uric acid(UA)and blood lipid levels in patients with hyperuricemia.Methods A total of 100 patients with hyperuricemia admitted to the hospital from March 2021 to December 2022 were selected and randomly divided into the observation group and the control group,with 50 cases in each group.The patients in the two groups were given routine lifestyle interventions and oral Allopurinol Sustained-Release Capsules,on this basis,the patients in the observation group were given modified Cangzhu Xiezhuo Drink.Both groups were treated for four weeks.Results The total effective rate in the observation group was 94.00%,which was significantly higher than 78.00%in the control group(P<0.05).Compared with those in the control group,the scores of traditional Chinese medicine(TCM)syndromes(joint pain,joint swelling,restricted activities,body coldness,body heat)after treatment in the observation group significantly decreased,the UA,potassium ions and sodium ions levels significantly decreased,the total cholesterol(TC)and triglyceride(TG)levels significantly decreased(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(12.00%vs.6.00%,P>0.05).Conclusion Compared with the use of allopurinol alone,the modified Cangzhu Xiezhuo Drink combined with allopurinol is more effective in improving the relevant clinical symptoms of patients with hyperuricemia,regulating the UA and electrolyte levels,and decreasing the blood lipid levels.
作者
刘晋利
王好宁
周鲁川
LIU Jinli;WANG Haoning;ZHOU Luchuan(Traditional Chinese Medicine Hospital of Neijiang,Neijiang,Sichuan,China 641100)
出处
《中国药业》
CAS
2024年第16期113-116,共4页
China Pharmaceuticals
基金
四川省中医药管理局科学技术研究专项课题[2020LC0155]。
关键词
加味苍术泄浊饮
高尿酸血症
电解质
痛风性关节炎
别嘌醇
血脂
临床疗效
modified Cangzhu Xiezhuo Drink
hyperuricemia
electrolyte
gouty arthritis
allopurinol
blood lipid
clinical efficacy
