摘要
目的:探讨25-羟维生素D(25-OH-D)、白细胞计数与平均血小板体积比值(WMR)及中性粒细胞与淋巴细胞比值(NLR)与女性早发冠心病患者冠状动脉病变程度及院内主要不良心血管事件(MACE)的相关性。方法:选择2020年1月—2021年12月宁夏回族自治区人民医院收治的200例女性冠心病患者作为研究组,根据发病年龄将研究组分为早发组(冠心病发病年龄≤65岁,n=120)和非早发组(冠心病发病年龄>65岁,n=80),同时选取年龄与早发组匹配的行冠状动脉造影示冠脉正常的健康女性200例作为对照组。采用Gensini评分评估冠状动脉病变严重程度,根据Gensini评分将早发组患者分为轻度病变组(≤30分),中度病变组(31~60分),重度病变组(>60分),患者均检测25-OH-D、WMR及NLR水平,比较对照组、早发组、非早发组25-OH-D、WMR、NLR水平,比较轻度病变组、中度病变组、重度病变组25-OH-D、WMR、NLR,分析25-OH-D、WMR、NLR与院内MACE事件相关性。结果:非早发组WMR、NLR高于对照组、早发组,早发组WMR、NLR高于对照组,非早发组25-OH-D低于对照组、早发组,早发组25-OH-D低于对照组,差异有统计学意义(P<0.05);重度病变组WMR、NLR高于轻度病变组、中度病变组,中度病变组WMR、NLR高于轻度病变组,重度病变组25-OH-D低于轻度病变组、中度病变组,中度病变组25-OH-D低于轻度病变组,差异有统计学意义(P<0.05);相关性分析结果显示,25-OH-D与Gensini评分呈负相关(r=-0.386,P<0.05),WMR、NLR与Gensini评分呈正相关(r=0.674、0.621,P<0.05);所有患者均随访12~24个月,平均(15.65±1.98)个月,根据早发组患者是否发生MACE,将患者分为非MACE组85例和MACE组35例,MACE组WMR、NLR高于非MACE组,25-OH-D低于非MACE组,差异有统计学意义(P<0.05);多因素分析显示,WMR、NLR是发生MACE的危险因素,25-OH-D是发生MACE的保护因素(P<0.05)。经受试者工作特征(ROC)曲线分析,25-OH-D、WMR、NLR联合评估敏感度
Objective:To investigate the correlation of 25-hydroxyvitamin D(25-OH-D),white blood cell count to mean platelet volume ratio(WMR)and neutrophil to lymphocyte ratio(NLR)and the degree of coronary artery disease and in-hospital major adverse cardiovascular events(MACE)in female patients with early-onset coronary heart disease.Method:A total of 200 female patients with coronary heart disease who admitted to People's Hospital of Ningxia Hui Autonomous Region from January 2020 to December 2021 were selected as the study group,the study group was divided into the early-onset group(age of onset of coronary heart disease≤65 years old,n=120)and the non-early-onset group(age of onset of coronary heart disease>65 years old,n=80)according to the age of onset,at the same time,200 healthy women with normal coronary angiography were selected as the control group.Gensini score was used to evaluate the severity of coronary artery disease,patients in the early-onset group were divided into the mild lesion group(≤30 scores),the moderate lesion group(31-60 scores)and the severe lesion group(>60 scores)according to Gensini score.The levels of 25-OH-D,WMR and NLR were detected in all patients,the levels of 25-OH-D,WMR and NLR in the control group,the early-onset group and the non-early-onset group were compared,the levels of 25-OH-D,WMR and NLR in the mild lesion group,the moderate lesion group and the severe lesion group were compared,the correlation between 25-OH-D,WMR,NLR and in-hospital MACE events was analyzed.Result:The WMR and NLR in the non-early-onset group were higher than those in the control group and the early-onset group,WMR and NLR in the early-onset group were higher than those in the control group,25-OH-D in the non-early-onset group was lower than that in the control group and the early-onset group,25-OH-D in the early-onset group was lower than that in the control group,the differences were statistically significant(P<0.05);the WMR and NLR in the severe lesion group were higher than those in the mild lesion gro
作者
朱芩
杨茜
单晓兰
申立波
ZHU Qin;YANG Qian;SHAN Xiaolan;SHEN Libo(People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750004,China;不详)
出处
《中外医学研究》
2024年第22期142-146,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
宁夏回族自治区卫生健康系统科研课题项目(2022-NWKY-007)。
