摘要
目的探讨全身炎症反应指数(SIRI)联合纤维蛋白原在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压患者中的预测价值。方法本研究为病例对照研究, 采用非随机抽样的方法收集2020年3月至2023年6月就诊于徐州医科大学第二附属医院的OSAHS患者202例, 所有患者均行多导睡眠监测。根据是否合并高血压, 将患者分为单纯OSAHS组(n=69)和OSAHS-高血压组(n=133)。根据高血压等级不同, 将OSAHS-高血压组又分成高血压1级(n=25)、2级(n=39)、3级(n=69)3个亚组。比较单纯OSAHS组和OSAHS-高血压组患者性别、年龄、身体质量指数(BMI)、白细胞、血小板、甘油三酯、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、纤维蛋白原、呼吸暂停低通气指数(AHI)、氧减饱和度指数(ODI)、最低血氧饱和度(LSpO2)、鼾声指数(SI)等指标, 计算并比较2组患者中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)、全身炎症反应指数(SIRI)和全身炎症综合指数(AISI)。比较OSAHS-高血压组3个亚组SIRI和纤维蛋白原。通过多因素logistic逐步回归分析探讨OSAHS合并高血压的影响因素, 利用Log P回归诊断评估模型绘制受试者操作特征(ROC)曲线分析纤维蛋白原、SIRI、二者联合检测在OSAHS-高血压中的预测价值。结果单纯OSAHS组69例, 男13例, 女56例, 年龄(49.76±11.73)岁;OSAHS-高血压组113例, 男13例, 女120例, 年龄(51.74±13.26)岁。2组患者性别、年龄、BMI、白细胞、血小板、甘油三酯、总胆固醇、HDL-C、LDL-C、PLR、AHI、ODI、LSpO2、SI比较差异均无统计学意义(均P>0.05)。OSAHS-高血压组纤维蛋白原、NLR、MLR、SIRI、AISI较单纯OSAHS组升高, 分别为(3.92±0.68)g/L比(3.62±0.62)g/L、2.11(1.73, 2.99)比1.87(1.49, 2.34)、0.29(0.22, 0.36)比0.22(0.17, 0.30)、1.14(0.86, 1.69)比0.83(0.62, 1.21)、237.07(171.19, 375.43)比181
Objective:To investigate the predictive value of systemic inflammatory response index(SIRI)combined with fibrinogen in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with hypertension.Methods:This was a case-control study.A non-random sampling method was used to collect 202 OSAHS patients who were admitted to the Second Affiliated Hospital of Xuzhou Medical University from March 2020 to June 2023.All patients underwentp olysomnography.According to the presence or absence of hypertension,the patients were divided into simple OSAHS group(n=69)and OSAHS-hypertension group(n=133).OSAHS-hypertension group was divided further into three subgroups:grade 1(n=25),grade 2(n=39),and grade 3(n=69).The gender,age,body mass index(BMI),white blood cells,platelets,triglycerides,total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fibrinogen,apnea hypopnea index(AHI),oxygen desaturation index(ODI),lowest oxygen saturation(LSpO 2),snoring index(SI),and other indicators were compared between the simple OSAHS group and the OSAHS-hypertension group.Neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR),systemic inflammatory response index(SIRI)and systemic inflammatory index(AISI)were calculated.SIRI and fibrinogen were compared among the three subgroups of OSAHS-hypertension group.Multivariate logistic regression analysis was used to explore the influencing factors of OSAHS complicated with hypertension.The receiver operating characteristic(ROC)curve was drawn by using the Log P regression diagnostic evaluation model to analyze the predictive value of fibrinogen and SIRI in OSAHS-hypertension.Results:There were 69 patients in the simple OSAHS group,including 13 males and 56 females,aged(49.76±11.73)years old.There were 113 patients in the OSAHS-hypertension group,including 13 males and 120 females,aged(51.74±13.26)years old.There were no significant differences in gender,age,BMI,white blood cells,platelet
作者
许乘铭
杭文璐
陈雷
王海清
Xu Chengming;Hang Wenlu;Chen Lei;Wang Haiqing(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Xuzhou Medical University,Xuzhou 221006,China)
出处
《国际呼吸杂志》
2024年第7期831-837,共7页
International Journal of Respiration
基金
徐州市科学技术局项目(KC22212)。
