摘要
目的:探讨妊娠期糖尿病孕妇分娩的新生儿发生低血糖的影响因素。方法:选取2021年2—10月在南通大学附属妇幼保健院住院的妊娠期糖尿病孕妇经阴道分娩的新生儿作为研究对象。收集妊娠期糖尿病孕妇的口服葡萄糖耐量试验值、糖化血红蛋白值、BMI、分娩孕周、总产程时间及新生儿的出生体质量、脐血血糖值等临床资料,并采用多元线性回归分析妊娠期糖尿病孕妇分娩的新生儿发生低血糖的影响因素。结果:共纳入536名新生儿,多元线性回归结果显示:孕周、分娩镇痛、脐血血糖、脐血pH值及新生儿出生体质量是新生儿发生低血糖的影响因素,这些变量可以解释新生儿出生后血糖变异的42.2%。其中,脐血血糖与新生儿出生半小时末梢血糖相关系数r=0.510,P<0.001。在控制混杂因素后,脐血血糖仍然是影响妊娠期糖尿病孕妇新生儿血糖的因素。结论:孕周、分娩镇痛、脐血血糖、脐血pH值及新生儿出生体质量是妊娠期糖尿病孕妇分娩的新生儿发生低血糖的主要影响因素;脐血血糖可作为预测新生儿低血糖的简易无创参考指标。
Objective:To explore the influencing factors of neonatal hypoglycemia in pregnant women with gestational diabetes mellitus.Methods:Pregnant women and newborns with gestational diabetes mellitus during vaginal delivery in the Affiliated Maternity and Child Health Care Hospital of Nantong University from February to October in 2021 were selected as the research object.The oral glucose tolerance test value,glycated hemoglobin value,BMI,gestational week,total duration of labor and newborn′s birth weight,umbilical blood glucose value and other clinical data were collected to analyze the influencing factors of hypoglycemia in newborns in pregnant women with gestational diabetes mellitus,and with multiple linear regression to analyse the influencing factors of neonatal hypoglycemia in pregnant women with diabetes during pregnancy.Results:A total of 536 newborns were included,and the results of multiple linear regression showed that the influencing factors of neonatal blood glucose include gestational week,labor analgesia,umbilical blood glucose,umbilical blood pH value,and newborn birth weight.These variables can explain 42.2%of post-natal blood glucose variation in newborns.Among them,the correlation coefficient between cord blood glucose and neonatal peripheral blood glucose at half an hour of birth is r=0.510,P<0.001.After controlling for the confounding factors,umbilical blood glucose is still the factor influencing the blood glucose of newborns in pregnant women with diabetes.Conclusion:Gestational week,labor analgesia,umbilical blood glucose,umbilical blood pH value and newborn birth weight are the main influencing factors of hypoglycemia in newborns of pregnant women with diabetes umbilical blood glucose can serve as a simple non-invasive reference indicator for predicting neonatal hypoglycemia.
作者
谷金丽
吴蓉蓉
张文秀
顾佳惠
刘华华
GU Jinli;WU Rongrong;ZHANG Wenxiu;GU Jiahui;LIU Huahua(Delivery Room,Affiliated Maternity and Child Health Care Hospital of Nangtong University,Jiangsu 226018)
出处
《南通大学学报（医学版）》
2024年第3期217-221,共5页
Journal of Nantong University(Medical sciences)
基金
南通市卫生健康委员会项目(MSZ2022046)
南通市科技局项目(MS22022100)
江苏省妇幼健康科研项目(F202047)。
关键词
妊娠期糖尿病
脐血
新生儿血糖
gestational diabetes mellitus
umbilical cord blood
newborn blood glucose
