摘要
目的探讨粪钙卫蛋白(FC)联合白蛋白对老年结肠息肉患者的诊断价值。方法回顾性分析2022年12月至2023年12月南京市浦口区中医院脾胃科收治的经内镜检查确诊为结肠息肉的200例患者(息肉组)临床资料,另选取同期接受内镜检查的200例无结肠息肉人群作为对照组。记录两组的基础资料及生化指标,检测FC水平,采用二分类Logistic回归模型分析结肠息肉发生的影响因素,绘制受试者工作特征(ROC)曲线,分析FC联合白蛋白对结肠息肉的诊断效能。结果两组的年龄、性别、白细胞计数(WBC)及C-反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05);息肉组的腹泻占比、FC、中性粒细胞(Neu)高于对照组,血红蛋白、白蛋白水平低于对照组,差异具有统计学意义(P<0.05)。二分类Logistic回归分析模型结果显示,FC、血红蛋白、白蛋白是结肠息肉形成的独立影响因素(P<0.05)。ROC曲线结果显示,FC、血红蛋白、白蛋白对结肠息肉均有一定诊断价值。FC诊断结肠息肉的ROC曲线下面积(AUC)为0.853,优于白蛋白(AUC=0.754)和血红蛋白(AUC=0.788),FC联合白蛋白对结肠息肉的诊断效能最高(AUC=0.909),诊断灵敏度为88.00%,特异度为81.00%。结论FC联合白蛋白用于老年结肠息肉患者的早期筛查具有较高的诊断价值,其简单、无创、灵敏度高,易于接受,可作为老年人群常规结肠息肉筛查的手段。
Objective To investigate the diagnostic value of fecal calprotectin(FC)combined with albumin in elderly patients with colonic polyps.Methods The clinical data of 200 patients(polyp group)diagnosed with colonic polyps by endoscopy in the spleen and stomach department of Pukou Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were retrospectively analyzed.In addition,200 patients without colonic polyps who underwent endoscopy during the same period were selected as control group.The basic data and biochemical indexes of the two groups were recorded,and the FC level was detected.The binary Logistic regression model was used to analyze the influencing factors of colonic polyps.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of FC combined with albumin for colonic polyps.Results There were no significant differences in age,gender,white blood cell count(WBC)and C-reactive protein(CRP)levels between the two groups(P>0.05);the proportion of diarrhea,FC and neutrophile granulocyte(Neu)in the polyp group were higher than those in the control group,and the levels of hemoglobin and albumin were lower than those in the control group,the differences were statistically significant(P<0.05).The results of binary Logistic regression analysis showed that FC,hemoglobin and albumin were independent influencing factors of colonic polyp formation(P<0.05).ROC curve results showed that FC,hemoglobin and albumin had certain diagnostic value for colonic polyps.The ROC areas under curve(AUC)of FC in the diagnosis of colonic polyps was 0.853,which was better than that of albumin(AUC=0.754)and hemoglobin(AUC=0.788).FC combined with albumin had the highest diagnostic efficiency for colonic polyps(AUC=0.909),the diagnostic sensitivity was 88.00%and the specificity was 81.00%.Conclusion FC combined with albumin has a high diagnostic value for early screening of elderly patients with colonic polyps.It is simple,non-invasive,sensitive and easy to accept,and can be used as a ro
作者
马兰
王霞
李扬
MA Lan;WANG Xia;LI Yang(Spleen and Stomach Department,Pukou Hospital of Traditional Chinese Medicine,Nanjing 211800,China)
出处
《临床医学研究与实践》
2024年第23期106-109,共4页
Clinical Research and Practice
基金
2020年度浦口区社会事业科技发展计划项目(No.S2020-10)。
关键词
结肠息肉
老年
粪钙卫蛋白
白蛋白
colonic polyp
elderly
fecal calprotectin
albumin
