摘要
目的探讨益肾通络方治疗肾虚络阻型少弱精子症不育患者的有效性与安全性。方法选取2022年1月—2022年12月于河南省中医院(河南中医药大学第二附属医院)生殖医学科门诊就诊的108例肾虚络阻型少弱精子症不育患者,随机分为试验组和对照组,每组54例。试验组给予益肾通络方,1剂/d,200 mL/次,分早、晚2次饭后1 h温服;对照组给予左卡尼汀口服溶液,10 mL/次,2次/d,餐时口服。两组疗程均为90 d,并于治疗开始前、30、60、90 d及治疗结束后3个月各随访1次。以精子浓度、精子总数、前向运动(progressive motility,PR)精子百分比、前向及非前向运动(progressive and non-progressive motility,PR+NP)(即总活力)精子百分比及配偶受孕率为主要疗效指标,以精液量、中医证候评分为次要疗效指标,比较两组临床疗效及患者治疗前后的症状改善情况,并观察记录患者的不良反应情况。结果治疗前后两组组内比较,精子浓度、精子总数、PR精子百分比、PR+NP精子百分比均显著改善(P<0.001);试验组精子浓度、精子总数、PR精子百分比、PR+NP精子百分比提升均优于对照组(P<0.001),而配偶受孕率两组差异无统计学意义(P>0.05)。治疗前后两组组内比较,仅试验组精液量提升、中医证候评分总分降低具有统计学意义(P<0.05);与对照组相比,试验组精液量差异无统计学意义(P>0.05),而3次同时期访视在降低中医证候评分总分方面均明显优于对照组(P<0.01),尤其在改善腰膝酸软,小腹、腹股沟或会阴部刺痛,头晕,耳鸣,神疲乏力,舌色紫黯,舌有瘀点或瘀斑,脉沉迟或涩等症状方面差异具有统计学意义(P<0.05)。研究结束后,试验组、对照组总有效率分别为88.00%(44/50)、66.67%(34/51),两组比较差异具有统计学意义(P<0.05)。两组患者在研究期间均未出现明显不良反应。结论采用益肾通络方治疗肾虚络阻型少弱精子症不育,临床疗效确�
Objective To investigate the efficacy and safety of Yishen Tongluo Formula(益肾通络方)in the treatment of oligoasthenozoospermia infertility with kidney deficiency and collateral obstruction.Methods A total of 108 oligoasthenozoospermia infertility patients with kidney deficiency and collateral obstruction were enrolled from January 2022 to December 2022 in the Reproductive Medicine Department of Henan Province Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine).They were randomly divided into experimental group and control group,with 54 cases in each group.The patients in the experimental group were given Yishen Tongluo Formula,one dose per day,200 mL per time,taking in the morning and evening.Those in the control group were given oral levocarnitine solution,10 mL for each time,twice a day,orally with meals.Both groups were treated for 90 days,and were followed up before treatment,30,60 and 90 days and 3 months after the end of treatment.The sperm concentration,total sperm count,the percentage of progressive motility(PR),the percentage of PR+non-progressive motility(NP),and the pregnancy rates were used as the main efficacy indicators,and the semen volume and TCM syndrome scores were used as the secondary efficacy indicators.The clinical efficacy and the improvement of symptoms before and after treatment were compared between the two groups,and the adverse reactions were observed and recorded.Results For intra-group comparison,compared with those before treatment,the sperm concentration,total sperm count,percentage of sperm in PR and percentage of sperm in PR+NP were significantly improved after the treatment in both groups(P<0.001).After treatment,compared with those of the control group,the sperm concentration,total sperm count,percentage of PR sperm and percentage of PR+NP sperm in the experimental group were significantly higher than those in the control group(P<0.001).However,there was no significant difference in the pregnancy rate of spouse
作者
孙自学
陈央娣
陈建设
吕水林
陈翔
李路凯
李鹏超
孙赫宇
SUN Zixue;CHEN Yangdi;CHEN Jianshe;LYU Shuilin;CHEN Xiang;LI Lukai;LI Pengchao;SUN Heyu(Henan Province Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China;Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第8期1-6,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81974573)
河南省“中原英才计划”中原名医项目(ZYMY201809)
河南省中医药科学研究重大专项(2022ZYZD9)
河南省防治生殖障碍疾病中医药重点实验室项目(2021ZDSYS10)
河南省重点科技攻关项目(222102310100)。
关键词
益肾通络方
少弱精子症
肾虚络阻
男性不育
Yishen Tongluo Formula(益肾通络方)
oligoasthenozoospermia
kidney deficiency and collateral obstruction
male infertility
