摘要
目的分析当前纳米颗粒在非小细胞肺癌(non-small cell lung cancer,NSCLC)治疗中的应用现状和研究热点,预测未来发展趋势。方法检索Web of Science数据库中关于纳米颗粒在NSCLC治疗中应用的研究,检索时间为建库至2022年11月。采用CiteSpace、VOSviewer和文献计量在线分析平台(https://bibliometric.com/)对文献数量、来源期刊、作者、机构、国家和关键词进行可视化分析。结果最终纳入英文文献742篇,文献发表数量从2011年开始逐年递增,2020年达到年发表量顶峰。纳米颗粒与NSCLC治疗的研究主要集中在中国、美国、印度和日本。我国是该领域的研究大国,但是缺少与其他国家或相关机构的合作。众多研究机构中,中国科学院是该研究领域发文量最多的机构,研究成果较为突出。关键词分析发现,从2018年开始“聚乳酸羟基乙酸共聚物纳米颗粒”和“光热疗法”成为最新的突现词。不仅如此,“药物递送”等相关关键词的出现频率显著增加,表明聚乳酸羟基乙酸共聚物纳米颗粒在光热疗法中的应用可能是当前NSCLC治疗的研究热点和未来的发展趋势。结论目前纳米颗粒与NSCLC治疗的国内研究在全球处于领先地位,选取不同材料的纳米颗粒并与其他NSCLC疗法进行有机结合有望改善NSCLC患者预后;在未来尝试开发不同来源与结构的纳米颗粒并辅以光热疗法进行NSCLC治疗可能成为纳米颗粒在NSCLC治疗中的研究热点。
Objective To analyze the current research application status and hotspots of nanoparticles in the treatment of non-small cell lung cancer(NSCLC)and predict the future development trend.Methods The Web of Science database was searched for literatures on nanoparticles use in the treatment of NSCLC from inception to November 2022.CiteSpace,VOSviewer and literature measurement analysis online platform(https://bibliometric.com/)were used for the visual analysis of the number of documents,source journals,authors,organizations,countries and keywords.Results A total of 742 English literatures were included.The results showed that the number of published literatures increased year by year from 2011 and reached the peak in 2020.Researches on nanoparticles and NSCLC treatment were mainly concentrated in China,the United States,India and Japan.China is a major research country in this field,but it lacked cooperation with other countries and related institutions.Among numerous research institutions,the Chinese Academy of Sciences was the authoritative and backbone force in this research field,with the number of published literatures ranking first and the research achievements outstanding.The keyword analysis found that"poly lactic-co-glycolic acid nanoparticles(PLGA NPs)"and"photothermal therapy"had become the latest breakout words since 2018.Moreover,the occurrence frequency of related keywords such as"drug delivery"increased significantly,indicating that the application of PLGA NPs in photothermal therapy might be the current research hotspot and future development trend of NSCLC treatment.Conclusion Currently,the domestic research on the treatment of nanoparticles and NSCLC is in a leading position in the world.The organic combination of nanoparticles with different materials and other NSCLC therapies is expected to improve the prognosis of NSCLC patients.In the future,attempts to develop nanoparticles with different sources and structures and combined with photothermal therapy for the treatment of NSCLC may become a resea
作者
徐翔宇
袁磊
孙飞
沈志明
单一波
卢毅
朱剑炜
陈文轩
史宏灿
XU Xiangyu;YUAN Lei;SUN Fei;SHEN Zhiming;SHAN Yibo;LU Yi;ZHU Jianwei;CHEN Wenxuan;SHI Hongcan(Clinical Medical College,Yangzhou University,Yangzhou,225009,Jiangsu,P.R.China;Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou,225009,Jiangsu,P.R.China;Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases,Yangzhou University,Yangzhou,225009,Jiangsu,P.R.China)
出处
《中国胸心血管外科临床杂志》
CSCD
北大核心
2024年第8期1139-1147,共9页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
纳米颗粒
非小细胞肺癌
文献计量学
可视化
Nanoparticles
non-small cell lung cancer
bibliometrics
visualization
