摘要
二萜化合物在植物、真菌、昆虫、海洋生物等中广泛存在,结构复杂、多变,生物活性多样。现概述天然二萜化合物抗肿瘤作用的相关通路及机制,从肿瘤信号通路的角度解析药物的抗肿瘤机制,为二萜化合物在抗肿瘤新药的研发及临床应用提供依据。
Diterpenoid compounds are widely distributed in plants,fungi,insects,and marine organisms,with complex and diverse structures and diverse biological activities.This article provides an overview of the relevant pathways and mechanisms of anti-tumor effects of natural diterpenoid compounds,analyzes the anti-tumor mechanism of drugs from the perspective of tumor signaling pathways,and provides a theoretical basis for the development and clinical application of diterpenoids in the development of anti-tumor new drugs.
作者
石小艺
程菊
陈建军
杨立苑
陈晓峥
刘秀珠
Amna RASHEED
谢小冬
SHI Xiaoyi;CHENG Ju;CHEN Jianjun;YANG Liyuan;CHEN Xiaozheng;LIU Xiuzhu;Amna RASHEED;XIE Xiaodong(Gansu University of Chinese Medicine,Lanzhou,Gansu,730000 P.R.China;Institute of Genetics,School of Basic Medicine,Lanzhou University,Lanzhou,Gansu,730000 P.R.China;State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu,730000 P.R.China)
出处
《华西药学杂志》
CAS
CSCD
北大核心
2024年第4期471-475,共5页
West China Journal of Pharmaceutical Sciences
基金
兰州市科技局新冠肺炎防控技术研究项目(2020-XG-37)
甘肃省科技重大专项项目(22ZD1FA001)。
关键词
天然化合物
二萜化合物
肿瘤
高效低毒
信号通路
分子机制
综述
Natural compounds
Diterpenoid compounds
Tumor
High efficiency and low toxicity
Signal pathway
Molecular mechanisms
Review
