摘要
目的探讨紧张型头痛(tension type headache,TTH)患者发作期、发作间期触觉辨别能力的变化及机制。方法该研究为横断面研究。收集2023年10月至2024年2月在中国人民解放军总医院第一医学中心头痛门诊就诊的TTH患者,包括发作期和发作间期各105例,另纳入109名志愿者作为健康对照组。收集受试者年龄、受教育时间、简易精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)评分等临床资料。通过触觉认知测试仪检测3组受试者的触觉辨别阈值,采用Kruskal-Wallis检验分析三组受试者触觉辨别阈值的差异。结果三组受试者年龄、受教育时间、MMSE、MoCA等一般资料差异无统计学意义(均P>0.05)。TTH患者合并焦虑抑郁者比例高于健康对照组(P<0.01)。通过协方差分析结果显示焦虑、抑郁与TTH对触觉辨别能力的影响的交互作用不显著。TTH患者发作期和发作间期组的触觉辨别阈值明显高于健康对照组(P<0.01),而TTH患者发作间期和发作期的触觉辨别阈值比较差异无统计学意义(P=1.000)。结论TTH患者发作期和发作间期的触觉认知水平均下降;触觉认知测试仪可识别TTH患者的早期触觉认知功能下降。
Objective To investigate the change and mechanism of tactile discrimination abilities in patients with ictal and interictal tension-type headache(TTH).Methods A cross-sectional study was conducted on patients with TTH who visited the headache clinic of the First Medical Center in the Chinese People's Liberation Army General Hospital from October 2023 to February 2024,including 105 patients with ictal TTH and 105 patients with interictal TTH.One hundred and nine volunteers were included as a healthy control group.Subjects ages,education years,mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA),self-rating anxiety scale(SAS),self-rating depression scale(SDS)were collected.Tactile cognition tester was used to detect the difference of tactile discrimination threshold of the three groups.We used Kruskal-Wallis test to analyze tactile discrimination thresholds among the three groups.Results There was no significant difference in age,education,MMSE,MoCA among the three groups(P>0.05).The proportion of TTH patients complicated with anxiety and depression was higher than that of healthy control group(P<0.01).The analysis of covariance showed that interaction between anxiety,depression and TTH on tactile discrimination was not significant.Kruskal-Wallis H test showed that the tactile discrimination thresholds of the patients with ictal and interictal TTH were significantly higher than those of the healthy control group(P<0.01)and tactile discrimination thresholds showed no statistical difference between interictal TTH group and ictal TTH group(P=1.000).Conclusions The tactile discrimination ability of TTH patients in ictal and inter ictal was decreased.Early decline in tactile cognitive function of the TTH patients can be identified by the tactile cognition tester.
作者
焦格
杜文娟
刘畅
于生元
JIAO Ge;DU Wenjuan;LIU Chang;YU Shengyuan(不详;General Internal Medicine of Eastern Medical Branch of PLA General Hospital,Beijing 101149,China)
出处
《中国神经免疫学和神经病学杂志》
CAS
2024年第4期283-287,共5页
Chinese Journal of Neuroimmunology and Neurology
关键词
紧张性头痛
触觉认知
触觉辨别阈值
焦虑
抑郁
tension type headache
tactile cognition
tactile discrimination threshold
anxiety
depression
