摘要
体外膜肺氧合技术用于对重症心肺功能衰竭患者提供持续的体外血液氧合以维持患者生命。为加速促进体外膜肺氧合技术的国产化进程,从氧合器的工作原理出发综述了国内体外膜肺氧合技术中氧合膜、离心泵、控制系统等关键技术的研究进展;针对氧合器卡脖子难题,主要介绍了氧合膜材料、制备方法的技术难题。结合3M样品的编织组织分析得出了聚甲基戊烯(PMP)中空纤维的膜织物样品幅宽、密度等关键参数,验证了PMP膜织物的编织组织为编链/衬纬组织,指出了氧合器技术的国产化需从PMP中空纤维制备的工艺优化和开发专用编织设备展开。最后提出未来体外膜肺氧合技术的发展需要多学科的技术交叉合作,实现从国产化向国际领先的技术转变。
Significance Extracorporeal Membrane Oxygenation(ECMO)is an extracorporeal life support method.Since the outbreak of COVID-19,ECMO has achieved remarkable clinical results despite the high cost of consumables.On the other hand,the shortage of ECMO equipment and technical reserves in China becomes increasingly prominent,making it urgent to breakthrough the core technology for domestic ECMO production.In March 2021,the national"Fourteenth Five-Year Plan and 2035 Vision and Goals Outline"was released,calling for breakthroughs in extracorporeal membrane oxygenation machine and other core technologies,and the innovation research and development of domestic ECMO technology has been upgraded to the height of the national strategy since then.As part of the national effort,this paper reviews the research progress of ECMO in China and and tries to point out the future research directions.Progress The working principle of ECMO extracorporeal membrane pulmonary oxygenation device was introduced in this review,and the centrifugal pump,control system,and oxygenator have been highlighted as the three key technologies for ECMO development.The progress of domestic research on the current technical difficulties was reviewed.Since the national policy was put forward,various medical research organizations have joined forces and overcome many key technologies of ECMO.The centrifugal pump in ECMO has been successively developed in China.The preparation technology of PMP(polymethylpentene)has been broken through,and the control system of ECMO equipment has been developed with the help of domestic leading aerospace technology.Since 2023,three ECMO products have been released domestically.The centrifugal pump product has a pump body speed of 7000 r/min,which is better than that of 3M′s 5000 r/min;the maximum flow rate can reach 8 L/min,which is on a par with the performance of 3M′s products.The porosity of domestic PMP membrane material can reach 60%,and the strength is more than 60 cN,which is the same as that of 3M products.Aiming
作者
席立锋
马丕波
贾伟
王佳冕
张红斌
彭小权
夏风林
蒋高明
XI Lifeng;MA Pibo;JIA Wei;WANG Jiamian;ZHANG Hongbin;PENG Xiaoquan;XIA Fenglin;JIANG Gaoming(Engineering Research Center for Knitting Technology,Ministry of Education,Jiangnan University,Wuxi,Jiangsu 214122,China;National Innovation Center for Advanced Medical Devices,Shenzhen,Guangdong 518100,China)
出处
《纺织学报》
EI
CAS
CSCD
北大核心
2024年第8期234-240,共7页
Journal of Textile Research
基金
深圳市科技重大专项课题(202327D238)
中央高校基本科研业务费专项资金资助、江苏省研究生科研与实践创新计划项目(KYCX24_2547)。
关键词
体外膜肺氧合技术
氧合器
聚甲基戊烯中空纤维
编织技术
extracorporeal membrane oxygenation technology
oxygenation equipment
polymethylpentene hollow fiber membrane
braiding technology
